Open Access

ARTICLE

Detection of Necroptosis in Ligand-Mediated and Hypoxia-Induced Injury of Hepatocytes Using a Novel Optic Probe-Detecting Receptor-Interacting Protein (RIP)1/RIP3 Binding

Sanae Haga^*, Akira Kanno^†, Takeaki Ozawa^‡, Naoki Morita^§, Mami Asano^*¶,¶ and Michitaka Ozaki^*¶

* Department of Biological Response and Regulation, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan
† Department of Environmental Applied Chemistry, Faculty of Engineering, University of Toyama, Toyama, Japan
‡ Department of Chemistry, School of Science, The University of Tokyo, Tokyo, Japan
§ Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Hokkaido, Japan
¶ Laboratory of Molecular and Functional Bio-Imaging, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan