Open Access

ARTICLE

Long Noncoding RNA NEAT1 Promotes Proliferation and Invasion via Targeting miR-181a-5p in Non-Small Cell Lung Cancer

ShiDong Li^*†, JiaMei Yang^†, Yubing Xia^‡, QingXia Fan^*, Kun-peng Yang^§

* Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
† Department of Oncology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
‡ Department of Radiotherapy, Kaifeng Cancer Hospital, Kaifeng, P.R. China
§ Department of Thoracic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China

Oncology Research 2018, 26(2), 289-296. https://doi.org/10.3727/096504017X15009404458675

Abstract

Long noncoding RNAs (lncRNAs) have been implicated in various biological processes and pathological conditions, including tumorigenesis. However, the exact roles of NEAT1 and its underlying mechanisms in nonsmall cell lung cancer (NSCLC) remain largely unclear. In the present study, lncRNA NEAT1 was detected to be significantly upregulated in NSCLC tissues and closely associated with advanced TNM stages, lymph node metastasis, distant metastasis, and poor prognosis. Further experiments revealed that lncRNA NEAT1 silencing inhibited cell proliferation and invasion in vitro. In addition, mechanistic analysis showed that lncRNA NEAT1 upregulated the miR-181a-5p-targeted gene HMGB2 through acting as a competitive “sponge” of miR-181- a-5p. In conclusion, our study suggested that lncRNA NEAT1 plays an oncogenic role in NSCLC progression and provides potential mechanisms by which lncRNA NEAT1 contributes to this disease.

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