Open Access

ARTICLE

Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor

Dina Polosukhina^*, Harold D. Love^*†, Harold L. Moses^‡§¶#, Ethan Lee^**††, Roy Zent^{†§**‡‡}, Peter E. Clark^*‡

* Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
† Department of Medicine (Nephrology and Hypertension), Vanderbilt University Medical Center, Nashville, TN, USA
‡ Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
§ Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA
¶ Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
# Department of Medicine (Hematology–Oncology), Vanderbilt University Medical Center, Nashville, TN, USA
** Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
†† Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
‡‡ Veterans Affairs Hospital, Nashville, TN, USA