Open Access
ARTICLE
Gamma Irradiation Upregulates B-cell Translocation Gene 2 to Attenuate Cell Proliferation of Lung Cancer Cells Through the JNK and NF-κB Pathways
Peihe Wang*, Yuanyuan Cai*, Dongju Lin†, Yingxiao Jiang*
* Department of Radiotherapy, Weifang People’s Hospital, Weifang, P.R. China
† Department of Reproduction, Weifang People’s Hospital, Weifang, P.R. China
Oncology Research 2017, 25(7), 1199-1205. https://doi.org/10.3727/096504017X14873444858101
14 June 2024 Editors Note:
Readers are alerted that concerns were raised about the integrity of some of the data presented in the article. Further editorial action will be taken once this matter has been resolved.
Abstract
Gamma ray can promote cancer cell apoptosis and cell cycle arrest. It is often used in the clinical treatment of
tumors, including lung cancer. In this study, we aimed to explore the role of gamma ray treatment and its correlation with BTG2 in cell proliferation, apoptosis, and cell cycle arrest regulation in a lung cancer cell line.
A549 cell viability, apoptosis rate, and cell cycle were investigated after gamma ray treatment. We then used
siRNA for BTG2 to detect the effect of BTG2 knockdown on the progress of gamma ray-treated lung cancer
cells. Finally, we investigated the signaling pathway by which gamma ray might regulate BTG2. We found that
gamma ray inhibited A549 cell viability and promoted apoptosis and cell cycle arrest, while BTG2 knockdown
could relieve the effect caused by gamma ray on A549 cells. Moreover, we confirmed that the effect of BTG2
partly depends on p53 expression and gamma ray-promoting BTG2 expression through the JNK/NF-kB signaling pathway. Our study assessed the possible mechanism of gamma ray in tumor treatment and also investigated the role of BTG2 in gamma ray therapy. All these findings might give a deep understanding of the effect
of gamma ray on the progression of lung cancer involving BTG2.
Keywords
Cite This Article
APA Style
Wang, P., Cai, Y., Lin, D., Jiang, Y. (2017). Gamma irradiation upregulates b-cell translocation gene 2 to attenuate cell proliferation of lung cancer cells through the JNK and NF-κB pathways. Oncology Research, 25(7), 1199-1205. https://doi.org/10.3727/096504017X14873444858101
Vancouver Style
Wang P, Cai Y, Lin D, Jiang Y. Gamma irradiation upregulates b-cell translocation gene 2 to attenuate cell proliferation of lung cancer cells through the JNK and NF-κB pathways. Oncol Res. 2017;25(7):1199-1205 https://doi.org/10.3727/096504017X14873444858101
IEEE Style
P. Wang, Y. Cai, D. Lin, and Y. Jiang "Gamma Irradiation Upregulates B-cell Translocation Gene 2 to Attenuate Cell Proliferation of Lung Cancer Cells Through the JNK and NF-κB Pathways," Oncol. Res., vol. 25, no. 7, pp. 1199-1205. 2017. https://doi.org/10.3727/096504017X14873444858101