Open Access
ARTICLE
Tumor Protein D52 (TPD52) Inhibits Growth and Metastasis in Renal Cell Carcinoma Cells Through the PI3K/Akt Signaling Pathway
Zhenhua Zhao1, Hui Liu1, Junqing Hou, Tieqiang Li, Xinyi Du, Xiaolei Zhao, Wenchao Xu, Weibo Xu, Junkai Chang
Department of Urology, Huaihe Hospital of Henan University, Kaifeng, P.R. China
Oncology Research 2017, 25(5), 773-779. https://doi.org/10.3727/096504016X14774889687280
Abstract
Tumor protein D52 (TPD52) is a member of the TPD52-like protein family and plays different roles in various types of malignancies. However, its role in renal cell carcinoma (RCC) is still unclear. In this study, we
investigated the role of TPD52 in RCC. The mechanism of TPD52 in RCC was also investigated. Our data
demonstrated that the expression levels of TPD52 in both mRNA and protein were significantly decreased
in RCC cells. Overexpression of TPD52 inhibited proliferation, migration, and invasion with decreased
epithelial–mesenchymal transition (EMT) phenotype in RCC cells, as well as attenuated tumor growth in
renal cancer xenografts. Mechanistically, overexpression of TPD52 significantly inhibited downregulated
phosphorylation levels of PI3K and Akt in RCC cells. In conclusion, the present study demonstrated that
TPD52 inhibited growth and metastasis of RCC, at least in part, by suppressing the PI3K/Akt signaling
pathway. Therefore, these findings suggest that TPD52 may be a promising therapeutic target for the treatment of human RCC.
Keywords
Cite This Article
APA Style
Zhao, Z., Liu, H., Hou, J., Li, T., Du, X. et al. (2017). Tumor protein D52 (TPD52) inhibits growth and metastasis in renal cell carcinoma cells through the pi3k/akt signaling pathway. Oncology Research, 25(5), 773-779. https://doi.org/10.3727/096504016X14774889687280
Vancouver Style
Zhao Z, Liu H, Hou J, Li T, Du X, Zhao X, et al. Tumor protein D52 (TPD52) inhibits growth and metastasis in renal cell carcinoma cells through the pi3k/akt signaling pathway. Oncol Res. 2017;25(5):773-779 https://doi.org/10.3727/096504016X14774889687280
IEEE Style
Z. Zhao et al., "Tumor Protein D52 (TPD52) Inhibits Growth and Metastasis in Renal Cell Carcinoma Cells Through the PI3K/Akt Signaling Pathway," Oncol. Res., vol. 25, no. 5, pp. 773-779. 2017. https://doi.org/10.3727/096504016X14774889687280