Open Access

ARTICLE

Long Noncoding RNA LINC00261 Suppresses Cell Proliferation and Invasion and Promotes Cell Apoptosis in Human Choriocarcinoma

Yinan Wang^*, Kai Xue^†, Yonghong Guan^*, Yuemei Jin^*, Shanshan Liu^*, Yichao Wang^*, Shuyan Liu^*, Ling Wang^*, Liying Han^*

* Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, P.R. China
† Department of Otolaryngology, The Second Hospital of Jilin University, P.R. China

Oncology Research 2017, 25(5), 733-742. https://doi.org/10.3727/096504016X14772362173376

Abstract

Choriocarcinoma is one of the gestational trophoblastic neoplasias (GTNs) that originate in the chorionic villi and the extravillous trophoblast. Long noncoding RNAs (lncRNAs) are a type of non-protein-coding RNAs that have recently been implicated in human tumorigenesis. The present study investigated the role of the lncRNA LINC00261 in cell proliferation, metastasis, and apoptosis in choriocarcinoma cell lines. The transcription level of LINC00261 was significantly lower in choriocarcinoma tissues and in choriocarcinoma cell lines. Overexpression of LINC00261 caused a decrease in cell proliferation and arrested the cell cycle at the G₀/G₁ phase. Furthermore, overexpression of LINC00261 inhibited cell migration and invasion. Meanwhile, it promoted cell apoptosis and the relative activities of caspase 3 and caspase 9 in choriocarcinoma JEG-3 and JAR cells. These data suggested that LINC00261 promotes cell proliferation and metastasis in choriocarcinoma. Our data might provide novel insight into the early diagnosis and treatment of choriocarcinoma in clinics.

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