Open Access

ARTICLE

MicroRNA-509-3p Inhibits Cancer Cell Proliferation and Migration via Upregulation of XIAP in Gastric Cancer Cells

Jihong Sun^*†1, Jingjing Li^‡1, Weiguo Zhang^*, Juan Zhang^*, Shenjie Sun^*, Guiqi Li^*, Hengliang Song^*, Daguo Wan^*

* Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
† Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
‡ Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
1 These authors provided equal contribution to this work.

Oncology Research 2017, 25(3), 455-461. https://doi.org/10.3727/096504016X14747283032017

Abstract

Gastric cancer (GC) is the fourth most common cancer globally. Recently, microRNAs (miRNAs) have been suggested to be closely associated with tumorigenesis. Aberrant expression of miR-509-3p has been reported in cancer studies. However, the expression and mechanism of its function in GC remain unclear. Here we showed that miR-509-3p was downregulated in GC specimens, which was associated with overall survival. Functional investigations demonstrated that the overexpression of miR-509-3p inhibited the migration and proliferation of the GC cells. Additionally, we identified X-linked inhibitor of apoptosis protein (XIAP) as a direct target of miR-509-3p. Knockdown of XIAP significantly attenuated the ability of proliferation, migration, and invasion of GC cells. The data therefore suggest that miR-509-3p plays an important role in the development and progression of GC, implicating possible applications in the clinic as a biomarker and a potential new target.

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