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Overexpression of SCUBE2 Inhibits Proliferation, Migration, and Invasion in Glioma Cells
Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China
Oncology Research 2017, 25(3), 437-444. https://doi.org/10.3727/096504016X14747335734344
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Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and explored its relevant mechanisms. The study showed that SCUBE2 had a low expression in glioma tissue and cell lines. SCUBE2 overexpression inhibited glioma cell proliferation in vitro and in vivo as well as suppressed glioma cell migration and invasion in vitro. Furthermore, we found that the Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. In light of the results obtained from our study, SCUBE2 may be regarded as a potential therapeutic target for glioma.Keywords
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2); Proliferation; Migration; Invasion; Glioma
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APA Style
Guo, E., Liu, H., Liu, X. (2017). Overexpression of SCUBE2 inhibits proliferation, migration, and invasion in glioma cells. Oncology Research, 25(3), 437-444. https://doi.org/10.3727/096504016X14747335734344
Vancouver Style
Guo E, Liu H, Liu X. Overexpression of SCUBE2 inhibits proliferation, migration, and invasion in glioma cells. Oncol Res. 2017;25(3):437-444 https://doi.org/10.3727/096504016X14747335734344
IEEE Style
E. Guo, H. Liu, and X. Liu "Overexpression of SCUBE2 Inhibits Proliferation, Migration, and Invasion in Glioma Cells," Oncol. Res., vol. 25, no. 3, pp. 437-444. 2017. https://doi.org/10.3727/096504016X14747335734344
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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