Ras-related protein 25 (Rab25) is a member of the Rab family, and it has been reported to play an important role
in tumorigenesis. However, its direct involvement in human glioblastoma multiforme (GBM) is still unclear. The
aim of the current study was to investigate the potential role of Rab25 in the growth, proliferation, invasion,
and migration of human GBM. Our results showed that Rab25 expression was significantly higher in human
GBM cell lines compared with a normal astrocyte cell line. In vitro functional studies revealed that knockdown
of Rab25 reduced cell proliferation and inhibited invasion and migration of GBM cells. In vivo experiments
showed that knockdown of Rab25 attenuated the tumor growth in nude mice. Finally, knockdown of Rab25
significantly inhibited the phosphorylation levels of PI3K and AKT in GBM cells. Taken together, these findings indicate that Rab25 may act as a tumor promoter in human GBM and that approaches to target Rab25 may
provide a novel strategy to treat this disease.
Cite This Article
APA Style
Ding, B., Cui, B., Gao, M., Li, Z., Xu, C. et al. (2017). Knockdown of ras-related protein 25 (rab25) inhibits the in vitro cytotoxicity and in vivo antitumor activity of human glioblastoma multiforme cells. Oncology Research, 25(3), 331-340. https://doi.org/10.3727/096504016X14736286083065
Vancouver Style
Ding B, Cui B, Gao M, Li Z, Xu C, Fan S, et al. Knockdown of ras-related protein 25 (rab25) inhibits the in vitro cytotoxicity and in vivo antitumor activity of human glioblastoma multiforme cells. Oncol Res. 2017;25(3):331-340 https://doi.org/10.3727/096504016X14736286083065
IEEE Style
B. Ding et al., "Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells," Oncol. Res., vol. 25, no. 3, pp. 331-340. 2017. https://doi.org/10.3727/096504016X14736286083065