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Tumor Necrosis Factor (TNF)-α-Induced Protein 8-like-2 (TIPE2) Inhibits Proliferation and Tumorigenesis in Breast Cancer Cells
Department of Breast Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P.R. China
Oncology Research 2017, 25(1), 55-63. https://doi.org/10.3727/096504016X14719078133320
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Tumor necrosis factor-a (TNF-a)-induced protein 8-like-2 (TNFAIP8L2 or TIPE2), a member of the tumor necrosis TNFAIP8 family, was found to be involved in the development and progression of several tumors. However, to date, the role of TIPE2 in breast cancer is still unclear. Thus, the aim of this study is to explore the role of TIPE2 in breast cancer. Our results indicated that TIPE2 expression was significantly decreased in human breast cancer tissue and cell lines. Overexpression of TIPE2 inhibited the proliferation in vitro and tumor xenograft growth in vivo. TIPE2 also inhibited the migration/invasion of breast cancer cells through preventing the epithelial-to-mesenchymal transition (EMT) phenotype. Mechanically, TIPE2 inhibited the expression of b-catenin, cyclin D1, and c-Myc in breast cancer cells. In conclusion, our findings show that TIPE2 may play an important role in breast cancer cell proliferation, invasion, and tumorigenesis in vivo. Therefore, TIPE2 may be a potential molecular target for the treatment of breast cancer.Keywords
Tumor necrosis factor (TNF)-α-induced protein 8-like-2 (TIPE2); Breast cancer; Invasion; Wnt/β-catenin pathway
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APA Style
Wang, K., Ren, Y., Liu, Y., Zhang, J., He, J. (2017). Tumor necrosis factor (tnf)-α-induced protein 8-like-2 (TIPE2) inhibits proliferation and tumorigenesis in breast cancer cells. Oncology Research, 25(1), 55-63. https://doi.org/10.3727/096504016X14719078133320
Vancouver Style
Wang K, Ren Y, Liu Y, Zhang J, He J. Tumor necrosis factor (tnf)-α-induced protein 8-like-2 (TIPE2) inhibits proliferation and tumorigenesis in breast cancer cells. Oncol Res. 2017;25(1):55-63 https://doi.org/10.3727/096504016X14719078133320
IEEE Style
K. Wang, Y. Ren, Y. Liu, J. Zhang, and J. He "Tumor Necrosis Factor (TNF)-α-Induced Protein 8-like-2 (TIPE2) Inhibits Proliferation and Tumorigenesis in Breast Cancer Cells," Oncol. Res., vol. 25, no. 1, pp. 55-63. 2017. https://doi.org/10.3727/096504016X14719078133320
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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