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Knockdown of Collagen Triple Helix Repeat Containing-1 Inhibits the Proliferation and Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma Cells
Department of Urology, China–Japan Union Hospital of Jilin University, Changchun, P.R. China
Oncology Research 2016, 24(6), 477-485. https://doi.org/10.3727/096504016X14685034103716
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Collagen triple helix repeat containing-1 (CTHRC1), a secreted glycoprotein, is frequently upregulated in human cancers. However, the functional role of CTHRC1 in renal cell carcinoma (RCC) remains unclear. Thus, the aim of this study was to explore the role of CTHRC1 in RCC. Our results demonstrated that CTHRC1 was upregulated in RCC tissues and cell lines. Knockdown of CTHRC1 significantly inhibits the proliferation in RCCs. Furthermore, knockdown of CTHRC1 significantly inhibited the epithelial-to-mesenchymal transition (EMT) process in RCCs, as well as suppressed RCC cell migration and invasion. Mechanistically, knockdown of CTHRC1 inhibited the expression of β-catenin, c-Myc, and cyclin D1 in RCC cells. In conclusion, the results of the present study indicated that CTHRC1 downregulation inhibited proliferation, migration, EMT, and β-catenin expression in RCC cells. Therefore, CTHRC1 may be a potential therapeutic target for the treatment of RCC.Keywords
Collagen triple helix repeat containing-1 (CTHRC1); Renal cell carcinoma (RCC); Invasion; Wnt/β-catenin signaling
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APA Style
Jin, X., Li, H., Zong, S., Li, H. (2016). Knockdown of collagen triple helix repeat containing-1 inhibits the proliferation and epithelial-to-mesenchymal transition in renal cell carcinoma cells. Oncology Research, 24(6), 477-485. https://doi.org/10.3727/096504016X14685034103716
Vancouver Style
Jin X, Li H, Zong S, Li H. Knockdown of collagen triple helix repeat containing-1 inhibits the proliferation and epithelial-to-mesenchymal transition in renal cell carcinoma cells. Oncol Res. 2016;24(6):477-485 https://doi.org/10.3727/096504016X14685034103716
IEEE Style
X. Jin, H. Li, S. Zong, and H. Li "Knockdown of Collagen Triple Helix Repeat Containing-1 Inhibits the Proliferation and Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma Cells," Oncol. Res., vol. 24, no. 6, pp. 477-485. 2016. https://doi.org/10.3727/096504016X14685034103716
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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