Table of Content

Open Access iconOpen Access

ARTICLE

miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line

Dayong Yan*1, Xiaoqing Cai*1, Yu Feng

* Oral and Maxillofacial Surgery, The Central Hospital of Zhengzhou, University of Zhengzhou, Zhengzhou, Henan, P.R. China
† Anesthesia Medicine, The Central Hospital of Zhengzhou, University of Zhengzhou, Zhengzhou, Henan, P.R. China
1 These authors provided equal contribution to this work.

Oncology Research 2016, 24(6), 399-404. https://doi.org/10.3727/096504016X14685034103239

A retraction of this article was approved in:

Retraction: miR-183 modulates cell apoptosis and proliferation in tongue squamous cell carcinoma SCC25 cell line
Read retraction

Abstract

This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as well as the expression of caspase 3 and BCL-xL, were detected. Results showed that miR-183 was significantly overexpressed in the SCC25 cell line when compared with normal control. The miR-183 inhibitor reduced cell growth and colony formation, while the apoptosis percentage was significantly increased. The expression of activated caspase 3 and BCL-xL was obviously up- and downregulated in siRNA-transfected cells, respectively. In conclusion, miR-183 contributed to cell growth and proliferation, and suppressed cell apoptosis in SCC25 cells. Therefore, miR-183 might serve as a therapeutic target in tongue squamous cell carcinoma (TSCC).

Keywords


Cite This Article

APA Style
Yan, D., Cai, X., Feng, Y. (2016). Mir-183 modulates cell apoptosis and proliferation in tongue squamous cell carcinoma SCC25 cell line. Oncology Research, 24(6), 399-404. https://doi.org/10.3727/096504016X14685034103239
Vancouver Style
Yan D, Cai X, Feng Y. Mir-183 modulates cell apoptosis and proliferation in tongue squamous cell carcinoma SCC25 cell line. Oncol Res. 2016;24(6):399-404 https://doi.org/10.3727/096504016X14685034103239
IEEE Style
D. Yan, X. Cai, and Y. Feng, “miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line,” Oncol. Res., vol. 24, no. 6, pp. 399-404, 2016. https://doi.org/10.3727/096504016X14685034103239



cc Copyright © 2016 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 175

    View

  • 139

    Download

  • 0

    Like

Share Link