Open Access

ARTICLE

Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway

Yu Wang^*†1, Hui Leng^†1, Hui Chen^*‡, Lei Wang^*, Nan Jiang^*, Xin Huo^†, Bin Yu^*

* Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China
† Department of Orthopaedics, Chifeng Hospital, Inner Mongolia, P.R. China
‡ Department of Pediatric Orthopaedics, the Second Hospital of Fuzhou Affiliated to Xiamen University, Fuzhou, P.R. China
1 These authors provided equal contribution to this work.

Oncology Research 2016, 24(5), 361-369. https://doi.org/10.3727/096504016X14685034103310

Abstract

Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the E2 family, was found to be overexpressed in a great many cancers such as bladder cancer, lung cancer, and prostate cancer. However, there have been no reports on the role of UBE2T in osteosarcoma. In this study, we tried to make the effects of UBE2T on osteosarcoma clear. The study results showed that UBE2T was overexpressed in osteosarcoma tissues and cell lines. Moreover, UBE2T knockdown inhibited osteosarcoma cell proliferation, migration, and invasion. We also observed that UBE2T downregulation could suppress the activity of the PI3K/Akt signaling pathway. Therefore, we concluded that UBE2T exerted its inhibitory effects on osteosarcoma cells via suppressing the PI3K/Akt signaling pathway. These findings indicated that UBE2T may be a potential therapeutic target for osteosarcoma treatment.

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