Open Access

ARTICLE

Thermal Radiofrequency Ablation as an Adjuvant Therapy for Patients With Colorectal Liver Metastasis

Yaohua Fan^*†1, Xiyan Zhu^*1, Qiuping Lan^*, Fang Lou^*, Yu Zheng^*, Haizhou Lou^*, Yong Fang^*, Wei Jin^*, Hongming Pan^*, Kaifeng Wang^*‡

* Department of Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
† Department of Oncology, Jiaxing the First Hospital, Jiaxing, China
‡ Cancer Center, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, China

Oncology Research 2015, 23(5), 219-228. https://doi.org/10.3727/096504016X14567549091260

Abstract

Radiofrequency ablation (RFA) is a minimally invasive technology for the treatment of liver malignancies and is used as an adjuvant therapy in patients with colorectal liver metastasis (CLM). This study enrolled a total of 49 CLM patients who underwent RFA treatment. Univariate and multivariate analyses were performed using the log-rank test and Cox proportional hazard model, respectively. Univariate analysis showed that OS was closely correlated with tumor size, frequency of RFA treatment, resection of the liver lesion, and CEA levels before RFA (p<0.05). Multivariate analysis revealed that resection of CLM lesions after RFA, frequency of RFA treatment, and serum CEA levels before RFA were independent risk factors for the survival of CLM patients (p<0.05). Tumor lesion size, resection of the liver lesion after RFA, frequency of RFA treatment, and serum CEA levels before RFA may be important prognostic factors of CLM patients treated with RFA therapy.

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Keywords

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