Guest Editors
Prof. Roman Paduch
E-mail: roman.paduch@mail.umcs.pl
Affiliation: Department of Virology and Immunology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19, 20-033, Lublin, Poland.
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Research Interests: Tumor microenvironment, Direct and paracrine interactions between tumor and normal cells, Immunology of tumor metastasis, three dimensional cell culture models
Summary
The tumor microenvironment is a complex network of direct and indirect interactions between cells and cells with extracellular substances. It regulates, especially in the context of solid tumors, its growth, vascularization, and metastasis. The tumor microenvironment is shaped not only by transformed cells, but also by immune cells, endothelial cells, fibroblasts, myeloid suppressor cells, macrophages, and others. Besides, they not only control the microenvironmental niche but also undergo functional changes under the influence of tumor cells, soluble factors, and so-called oncometabolites. The pro-inflammatory, immunosuppressive, and vascularization-stimulating tumor environment allows it to evade recognition and attack by the host's effector immune cells, as well as to rapidly spread to adjacent tissues and distant organs.
In this Special Issue, we also accept articles concerning issues close to its mainstream and including similar issues related to, e.g. immunotherapy targeted to tumor microenvironment or therapies involving the breakdown of immunosuppressive mechanisms related to the structure of the tumor.
We invite to this Special Issue submissions providing a new look at the relationships involving the interactions of the components that form the structure of cancer and its consequences as well as all aspects of direct and paracrine interactions within the tumor leading to its growth and spread in the body.
Keywords
Tumor microenvironment, Cellular interactions, Tumor stroma, Soluble mediators in tumor microenvironment, Tumor-infiltrating immune cells, Cellular and non-cellular components of the tumor structure
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