Features and Biomarkers of Microenvironment in Tumorigenesis and Metastasis

Submission Deadline: 30 April 2023 (closed)

Guest Editors

Heming Lu, Guangxi Academy of Medical Sciences and People’s Hospital of Guangxi Zhuang Autonomous Region, China. E-mail: luhming3632@163.com
Jian Song, University of Muenster, Germany. Email: songj@uni-muenster.de
Zhenming Fu, Renmin Hospital of Wuhan University, China. E-mail: davidfuzming@whu.edu.cn
Liangfang Shen, Xiangya Hospital Central South University, China. E-mail: slf1688@sina.com
Lingzhang Meng, Youjiang Medical University for Nationalities, China. E-mail: lingzhang.meng@ymun.edu.cn


Today, high-precision radiotherapy, molecular targeted therapy and immunotherapy have opened up new trends in oncology treatment, but how to deal with tumor resistance or ineffectiveness to these treatments has become a new challenge. The tumor microenvironment (TME) is considered a major factor in tumor development and drug resistance. TME includes cellular and non-cellular components, such as peritumor vasculature, immune cells, fibroblasts, myeloid-derived inflammatory cells and extracellular matrix that can influence tumorigenesis, growth, invasion, metastasis and response to therapy. Increasingly, researchers are focusing on TME to aid in the diagnosis of cancer and the development of therapeutic agents.


There are still many questions that need to be addressed to advance the study of the tumor microenvironment. How can the unique features of the tumor microenvironment be identified, what are the molecular mechanisms behind these features, and which signaling pathways are more important for tumor metastasis and recurrence? How can micrometastases be identified early and the seeds of metastasis be nipped in the bud? What are the temporal and spatial characteristics of tumor metastasis? How can therapeutic approaches targeting the microenvironment be effectively used to reduce the risk of tumor recurrence?


Therefore, in order to identify key features and reveal their role in TME, this special issue aims to focus on the progress of research on novel biochemical mechanisms of tumor microenvironmental features in various tumors. We welcome submissions of original research and review articles, including basic and clinical studies, as well as technical applications of tumor microenvironmental features.


Potential topics include, but are not limited to, the following.

1. Identification of key TME features involved in cancer progression and metastasis.

2. Novel biomarkers of therapeutic response in cancer patients, including but not limited to radiotherapy, chemotherapy, and immunotherapy.

3. Novel mechanisms of activation, migration, and infiltration of the tumor microenvironment.

4. Multi-omics reveals mechanisms of cross-talk between cancer cells and cells of the tumor microenvironment.

5. Single-cell sequencing reveals heterogeneity of immune cells and mechanisms of inflammatory remodeling in the tumor microenvironment.

6. Tumor microenvironment biomarkers such as circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), mRNA, microRNA (miRNA), circulating RNA (circRNA), exosomal RNA (exRNA) and long non-coding RNA (IncRNA) for regulation of the tumor microenvironment.

7. Intratumor microbiota influences the tumor microenvironment.

8. Anti-inflammatory or pro-inflammatory drugs and their mechanisms associated with response or sensitivity to cancer immunotherapy.

9. Immune neoantigens involved in the inflammatory response during tumor immunotherapy.


Tumor microenvironment, Tumourigenesis, Metastasis, Biomarkers, Cancer treatment

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