Guest Editors
Hiroyuki Osada, University of Shizuoka, Japan. Email: osadahiro@u-shizuoka-ken.ac.jp;
Herbert Waldmann, Max-Planck-Institute of Molecular Physiology, Department of Chemical Biology, Germany. Email: herbert.waldmann@mpi-dortmund.mpg.de;
Haian Fu, Department of Pharmacology and Chemical Biology, Emory University School of Medicine, USA. Email: hfu@emory.edu
Summary
Chemical biology is a research field which integrates multi-discipline and has yielded various small molecules such as probes and inhibitors. Cancer research is one of the most successful areas for chemical biology. Screening of anticancer drugs targeting oncogenes enabled new drug discovery. Imatinib, an inhibitor against Bcr-abl kinase, is the most prominent example and development of series of tyrosine kinase inhibitors was followed. Recent discovery of anti-cancer drugs targeting oncogenes, cancer metabolism and epigenetics will be compiled.
The aim of this special issue is to compile advancing knowledge of chemical biology for cancer research.
Keywords
probe, inhibitor, tyrosine kinase, oncogene, cancer metabolism, epigenetics
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