Guest Editors
Nicola Silvestris, Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy. Email: nsilvestris@unime.it;
Pascal H. G. Duijf, Translational Research Institute, University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia. Email: pascal.duijf@qut.edu.au;
Afshin Derakhshani, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada. Email: afshin.derakhshani@ucalgary.ca;
Behzad Baradaran, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Email: baradaranb@tbzmed.ac.ir;
Mahdi Abdoli Shadbad, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Email: abdolim@tbzmed.ac.ir;
Nima Hemmat, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Email: hemmatm@tbzmed.ac.ir
Summary
Non-coding RNAs are a group of RNA molecules that do not serve as a protein templet. It is well-established that non-coding RNAs substantially regulate post-transcriptional gene expression. Non-coding RNAs regulate various cellular processes, and dysregulated RNA expression has been implicated in cancer development. Long non-coding RNA (lncRNA), circular RNA (circRNA), and microRNA (miR) belong to the non-coding RNAs that have pivotal roles in cancer development and metastasis. Growing evidence has shown that specific circRNAs can sponge specific microRNAs, regulating the expression of tumor-suppressive and oncogenes. Since miRs can regulate a wide range of mRNA expression, identifying these axes can serve as a potential therapeutic avenue to enhance the chemo and radiosensitivity of tumoral cells, increase the efficacy of immunotherapeutic approaches, and inhibit tumor growth and metastasis. In this regard, the application of system biology approaches and advanced bioinformatic investigations, e.g., single-cell RNA sequencing, have further provided novel insights into the significance of human and viral non-coding RNAs in cancer development.
In this special issue, we welcome narrative reviews, original works, systematic reviews, in-silico investigations, and scoping reviews studying the significance of human and viral non-coding RNAs and the related axes in human cancer development. Also, we welcome the submissions highlighting the potentialities of these non-coding RNAs in enhancing the treatment of human cancers.
Keywords
Non-coding RNAs, Neoplasms, Bioinformatics, Cancer treatment, Post-transcriptional regulation
Published Papers
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