Guest Editors
Hao Zhang, Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, China. E-mail: zhsw@hospital.cqmu.edu.cn
Nan Zhang, Biology Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China. E-mail: awekevin@onethird-lab.com
Kui Zhang, The Pritzker School of Molecular Engineering, The University of Chicago, United State. E-mail:Zhangk87@gmail.com; kuizhang@uchicago.edu
Summary
In this era of precision medicine and exciting advances, drug resistance remains an essential obstacle to cancer treatment. The development of targeted therapy based on increasingly revealed pathogenic mechanisms of cancer has contributed to overcoming drug resistance. The use of model organisms in target discovery and validation of small molecule drugs is becoming commonplace. A critical objective of this topic is the target discovery and validation of small-molecule drugs. Another important aspect of this topic is describing and elucidating novel molecular targets and pathways and insights into precision medicine.
Multi-omics approaches have emerged as powerful tools to investigate the complex nature of cancer and its response to therapy. These approaches integrate data from various sources, such as genomics, transcriptomics, proteomics, and metabolomics, to provide a comprehensive view of the molecular landscape of tumors. Using multi-omics approaches, researchers can identify new biomarkers, pathways, and targets that can guide the development of personalized cancer therapy.
This topic does not accept simple bioinformatics analysis studies that are not accompanied by in vitro or in vivo experiments for validation.
Potential topics include but are not limited to the following:
1. Bioinformatics research with validation to identify novel biomarkers and models based on cancer immunotherapy patients;
2. Pathogenic mechanisms of cancer in drug resistance;
3. Novel targeted therapy of cancer based on newly defined molecular mechanisms;
4. Biomarkers for cancer development;
5. The target discovery and validation of small-molecule drugs.
Keywords
Multi-omics; Drug Resistance; Biomarker; Molecular Target.
Published Papers
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