Guest Editors
Huashan Shi, Cancer Center, West China Hospital, Chengdu, China. E-mail: shihuashan@scu.edu.cn
Yingfeng Wan, Department of Neurosurgery, Medical School,University of Michigan, Ann Arbor, USA. E-mail: yingfenw@med.umich.edu
Xuyu Gu, Department of Oncology, Zhongda Hospital, School of medicine, Southeast University, Nanjing, China. E-mail: guxuyu@126.com
Jian Zhang, School of Computer and Information Technology, Xinyang Normal University, Xinyang, Henan, China. E-mail: jianzhang@xynu.edu.cn
Haiting Chai, Nuffield Department of Medicine, University of Oxford, UK. E-mail: haiting.chai@ndm.ox.ac.uk
Summary
Cells require energy to maintain their survival, and various metabolites are also bioactive. It has now been recognized that metabolism regulates the phenotype and biological function of cells. In the tumor microenvironment (TME), tumor cells and immune cells reprogram their metabolic patterns to adapt to the hypoxic, acidic, and low-nutrition microenvironment. The crosstalk between tumor cells and immune cells in the TME manipulates the development of tumors. Although the recent advancement of immunotherapy was encouraging, and countless patients have achieved significant benefits, some patients still do not respond to immunotherapy, due to the complexity and diversity of the TME. Exploring the underlying mechanisms of TME-driven tumorigenesis and progression are essential for developing potential precise approaches for cancer treatment. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer.
This topic will include updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment. We welcome submissions of Original Research, Reviews, Mini-Reviews, Opinions and Perspective Articles covering, but not limited to, the following topics:
(1) The crosstalk between tumor cells and immune cells
(2) Mechanisms of changes in metabolism of functional immune cells (including suppressive and killer immune cells) in cancers
(3) The impact of metabolism of cancer cells and immune cells on immunotherapy
Keywords
metabolism, glycolysis, oxidative phosphrylation, tumor microenvironment, immune cells, glutaminolysis, T cells, macrophages, immunotherapy
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