Guest Editors
Yuseok Moon, Pusan National University, Korea. E-mail: muconetworklab@gmail.com
Arulkumar Nagappan, Pusan national university, Korea. E-mail: arulbiotechtnau@gmail.com
Summary
This issue aims to explore the critical role of metabolic reprogramming in cancer stemness, development, progression, and microenvironment. Metabolic reprogramming, characterized by one representative feature of the cellular shift from oxidative phosphorylation to glycolysis even in the presence of oxygen (the Warburg effect), has been considered a hallmark of cancer, but there is huge heterogeneity in the metabolic shifts. This metabolic switch supports the rapid proliferation and chemoresistance of tumor cells by supplying necessary biosynthetic intermediates, maintaining redox balance, and creating an acidic microenvironment conducive to invasion and metastasis. The intricate or external factors driving this reprogramming or its interventions are of significant interest in the cancer research community. We seek manuscripts that delve into the molecular and cellular mechanisms underlying metabolic reprogramming and intervention in cancer.
Topics of interest include but are not limited to:
· Molecular Drivers of Metabolic Reprogramming and Plasticity
· Therapeutic or Preventive Strategies Targeting Metabolic Reprogramming and Plasticity
· Tumor Niche, Stemness, and Metabolic Interplay
· Any other Challenges and Future Directions on addressing tumor heterogeneity and
metabolic plasticity in therapy resistance, identifying biomarkers for predicting tumor metabolic phenotypes and treatment responses, and innovations in personalized metabolic therapies tailored to individual tumors.
Keywords
Metabolic Reprogramming, Plasticity, Mitochondria, Cancer Stemness, Therapeutic Interventions, Chemoresistance, Tumor Microenvironment, Tumor stemness, Chemoprevention
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