Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses

Submission Deadline: 30 June 2023 (closed) View: 176

Guest Editors

Muhammad Muddassir Ali, University of veterinary and animal sciences Lahore Pakistan, Pakistan. E-mail: Muddassir.ali@uvas.edu.pk
Ibrahim Hakki cigerci, Afyonkocatepe University, Afyonkarahisar Turkey. E-mail: cigerci@aku.edu.tr
Cherif ABDENNOUR, University Badji Mokhtar-Annaba, Annaba, Algeria. Email: cherifabdennour@yahoo.fr

Summary

Reactive oxygen species and free radicals lead to genotoxic effects and mutations. These cascades play pivotal role in the development of tumour and tumor immunological response. After exposure to exogenous and endogenous factors, DNA damage and repair response is initiated inside the cells. Various pathways like mismatch repair (MMR) pathway, non-homologous end joining (NHEJ) pathway nucleotide excision repair (NER) pathway, base excision repair (BER) pathway, and the homologous recombination (HR), etc are activated. Moreover, various signaling pathways are also involved and taken as biomarkers in the early diagnosis and treatment of various cancers, e.g., androgen receptor signaling pathway, hippo signaling, and HGF/Met pathway, etc. All these factors, pathways, and mechanisms play an important role in the diagnosis, prevention, and therapeutic applications of various tumors and understanding immunological response. Therefore, it is inevitable to explore and study biomarkers related to the oxidative stress, DNA damage, and repair involved in cancer diagnosis and treatment.

The aim of this Special Issue is to publish high-quality original research as well as review articles about the role of redox homeostasis in cancer biology, Epigenetic regulation of cancer, biomarkers for diagnosis of tumors, Tumor microenvironment, cytogenesis in tumor microenvironment and role of various biological biomarkers in tumor immunology.

Keywords

DNA Damage, Neoplasms, Bioinformatics, Tumor microenvironment, Cancer treatment, Tumor micro environment, Tumour immunology, Oxidative stress

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ARTICLE

Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma
JIJIE XIAO, HONG XIAO, YUJUN CAI, JIANWEI LIAO, JUE LIU, LIN YAO, SHAOLIN LI
Oncology Research, Vol.32, No.4, pp. 691-702, 2024, DOI:10.32604/or.2023.030767
（This article belongs to the Special Issue: Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses)
Abstract Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the photosensitizer Chlorin e6 (Ce6) and CD47 monoclonal antibodies (aCD47), to deliver synergistic photodynamic and immunotherapy of osteosarcoma. On laser irradiation, Ce6 can generate More >
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Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway, and induces senescence in hepatocellular carcinoma
XUEGANG YANG, XIANHONG XIANG, GUOHUI XU, SHI ZHOU, TIANZHI AN, ZHI HUANG
Oncology Research, Vol.32, No.1, pp. 213-226, 2024, DOI:10.32604/or.2023.030768
（This article belongs to the Special Issue: Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses)
Abstract Hepatocellular carcinoma (HCC), a common malignancy worldwide, still lacks effective clinical treatment. The study aimed to investigate the oncogenes that affect the progression of HCC and their possible mechanisms. In our study, we initially confirmed a higher level of PRDX2 in the bile of HCC patients compared to those with choledocholithiasis by 2-DE, LC-MS, and ELISA. Subsequently, we demonstrated the high expression of peroxiredoxin 2 (PRDX2) in HCC based on the TCGA database and clinical sample analysis. Furthermore, PRDX2 overexpression enhanced the viability of HCC cells. And PRDX2 silencing induced senescence of HCC cells. In vivo, More >

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ScRNA-seq reveals the correlation between M2 phenotype of tumor-associated macrophages and lymph node metastasis of breast cancer
JUN SHEN, HONGFANG MA, YONGXIA CHEN, JIANGUO SHEN
Oncology Research, Vol.31, No.6, pp. 955-966, 2023, DOI:10.32604/or.2023.029638
（This article belongs to the Special Issue: Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses)
Abstract The process of lymphatic metastasis was proved to be associated with podoplanin-expressing macrophages in breast cancer (BC). This study aimed to investigate the role of the M2 phenotype of tumor-associated macrophages and mine the key M2 macrophages-related genes for lymph node metastasis in BC. We downloaded the GSE158399 dataset from the Gene Expression Omnibus (GEO) database, which includes transcriptomic profiles of individual cells from primary tumors, negative lymph nodes (NLNs), and positive lymph nodes (PLNs) of breast cancer patients. The cell subsets were identified by clustering analysis after quality control of the scRNA-seq using Seurat.… More >

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Prognostic-related genes for pancreatic cancer typing and immunotherapy response prediction based on single-cell sequencing data and bulk sequencing data
XUEFENG WANG, SICONG JIANG, XINHONG ZHOU, XIAOFENG WANG, LAN LI, JIANJUN TANG
Oncology Research, Vol.31, No.5, pp. 697-714, 2023, DOI:10.32604/or.2023.029458
（This article belongs to the Special Issue: Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses)
Abstract Background: Pancreatic cancer is associated with high mortality and is one of the most aggressive of malignancies, but studies have not fully evaluated its molecular subtypes, prognosis and response to immunotherapy of different subtypes. The purpose of this study was to explore the molecular subtypes and the key genes associated with the prognosis of pancreas cancer patients and study the clinical phenotype, prognosis and response to immunotherapy using single-cell seq data and bulk RNA seq data, and data retrieved from GEO and TCGA databases. Methods: Single-cell seq data and bioinformatics methods were used in this… More >

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Construction of the panoptosis-related gene model and characterization of tumor microenvironment infiltration in hepatocellular carcinoma
XINRUI SHI, XIA GAO, WENCONG LIU, XUEJIAO TANG, JIAYI LIU, DONGCHEN PAN, XUEQING DUAN, YUQING JIN, WEIYAN REN, LEI YANG, WENXUAN LIU
Oncology Research, Vol.31, No.4, pp. 569-590, 2023, DOI:10.32604/or.2023.028964
（This article belongs to the Special Issue: Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses)
Abstract Hepatocellular carcinoma (HCC) is the most common fatal cancer worldwide, patients with HCC have a high mortality rate and poor prognosis. PANoptosis is a novel discovery of programmed cell death associated with cancer development. However, the role of PANoptosis in HCC remains obscure. In this study, we enrolled 274 PANoptosisrelated genes (PANRGs) and screened 8 genes to set up a prognostic model. A previous scoring system calculated PANscore was utilized to quantify the individual risk level of each HCC patient, and the reliability of the prognostic model has been validated in an external cohort. Nomogram More >

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Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways
YAPING GAN, TING LIU, WEIFENG FENG, LIANG WANG, LI LI, YINGXIA NING
Oncology Research, Vol.31, No.3, pp. 333-343, 2023, DOI:10.32604/or.2023.028694
（This article belongs to the Special Issue: Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses)
Abstract Various therapeutic strategies have been developed to overcome ovarian cancer. However, the prognoses resulting from these strategies are still unclear. In the present work, we screened 54 small molecule compounds approved by the FDA to identify novel agents that could inhibit the viability of human epithelial ovarian cancer cells. Among these, we identified disulfiram (DSF), an old alcohol-abuse drug, as a potential inducer of cell death in ovarian cancer. Mechanistically, DSF treatment significantly reduced the expression of the anti-apoptosis marker B-cell lymphoma/leukemia-2 (Bcl-2) and increase the expression of the apoptotic molecules Bcl2 associated X (Bax)… More >

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Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses

Guest Editors

Summary

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Published Papers

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1386

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338

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821

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434

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1271

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398

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614

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2692

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821

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1461

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718

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