Guest Editors
Dr. Nethaji Muniraj
Email: nmuniraj@childrensnational.org
Affiliation: Center for Cancer and Immunology Research, Children's National Hospital, 111 Michigan Avenue NW, Washington, DC 20010, USA.
Homepage:
Research Interests: CAR-T & CAR-NK cell therapy, Treatment for Solid tumors
Summary
Immunotherapy has emerged as a revolutionary approach in cancer treatment, offering new hope for patients with various malignancies. Tumors often develop mechanisms to evade immune detection, such as upregulating immune checkpoint molecules like PD-L1 or suppressing T-cell activity. By harnessing the body's immune system to target and eliminate cancer cells, immunotherapy has the potential to achieve long-lasting remission and, in some cases, even a cure. This innovative strategy marks a significant departure from traditional cancer treatments, which primarily focus on directly targeting tumors through surgery, radiation, or chemotherapy.
Despite its promise, immunotherapy faces several challenges, including variability in patient responses, the development of resistance, and the occurrence of immune-related adverse events. These challenges underscore the complexity of the immune system's interaction with cancer and highlight the need for continued research to optimize treatment strategies.
This Special Issue will explore the current landscape of immunotherapy in cancer, focusing on the mechanisms by which the immune system can be activated or suppressed in the context of cancer. It will also examine the latest advances in immunotherapeutic agents, including checkpoint inhibitors, CAR-T cell therapy, and cancer vaccines. Furthermore, the issue will address the challenges of immunotherapy, such as identifying biomarkers for response prediction, managing resistance, and minimizing toxicity. Finally, the implications of immunotherapy for the future of cancer treatment and the potential for combination therapies will be discussed, emphasizing the need for ongoing research and innovation in this rapidly evolving field.
This vision not only aspires to cure more patients but also redefines how we approach cancer treatment—with precision, personalization, and hope.
Keywords
Immunotherapy, checkpoint inhibitors, CAR-T cell therapy, cancer vaccines, resistance mechanisms, biomarkers
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