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Biological roles and molecular mechanism of circular RNAs in epithelial-mesenchymal transition of gastrointestinal malignancies

ZIYI FANG1,2, YONGFU SHAO1,2,*, MENG HU1, JIANING YAN2, GUOLIANG YE2,*
1 School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, 315211, China
2 Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, 315020, China
* Corresponding Author: YONGFU SHAO. Email: email; GUOLIANG YE. Email: email,email
(This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)

Oncology Research https://doi.org/10.32604/or.2024.051589

Received 09 March 2024; Accepted 13 June 2024; Published online 19 July 2024

Abstract

Circular RNAs (circRNAs) are formed by splicing of precursor RNAs and covalently linked at the 5′ and 3′ ends. Dysregulated circRNAs are closely related to the epithelial-mesenchymal transition (EMT) of gastrointestinal malignancies. CircRNAs, including circRNA_0008717, circGOT1, circ-DOCK5, circVPS33B, circPVT1, circMET, circ-OXCT1, circ_67835, circRTN4, circ_0087502, circFNDC38, circ_PTEN1, circPGPEP1, and circ-E-Cad are involved in the EMT process of gastrointestinal malignancies through a variety of mechanisms, such as regulating EMT-inducing transcription factors, signaling pathways, and tumor microenvironments. Gastrointestinal (GI) malignancies are common malignant tumors worldwide, and the heterogeneity and easy metastasis of gastrointestinal malignancies limit the effectiveness of medical treatments. Therefore, investigating the molecular mechanisms involved in the pathogenesis of gastrointestinal malignancies is essential for clinical treatment. This article summarizes the biological roles and molecular mechanism of circRNAs in EMT of gastrointestinal malignancies, providing a theoretical basis for applying EMT-related circRNAs in targeted therapy.

Graphical Abstract

Biological roles and molecular mechanism of circular RNAs in epithelial-mesenchymal transition of gastrointestinal malignancies

Keywords

Epithelial-mesenchymal transition; Circular RNAs (circRNAs); Gastrointestinal malignancies

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