Open Access

REVIEW

Research progress on the role of decorin in the development of oral mucosal carcinogenesis

YONG RAO^1,3,4, XIAO CHEN^5,6, KAIYU LI^1,3,4, MINHAI NIE^1,3,4, XUQIAN LIU^2,3,4,*
1 Department of Periodontics and Oral Mucosal Diseases, The Afliated Stomatology Hospital, Southwest Medical University, Luzhou, 646000, China
2 Department of Basic Medicine of Stomatology, The Afliated Stomatology Hospital, Southwest Medical University, Luzhou, 646000, China
3 Institute of Stomatology, Southwest Medical University, Luzhou, 646000, China
4 Luzhou Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Luzhou, 646000, China
5 Department of Oral Medical Technology, Sichuan College of Traditional Chinese Medicine, Mianyang, 621000, China
6 Department of Orthodontics, Mianyang Stomatological Hospital, Mianyang, 621000, China
* Corresponding Author: XUQIAN LIU. Email:

Oncology Research https://doi.org/10.32604/or.2024.053119

Received 24 April 2024; Accepted 12 June 2024; Published online 12 July 2024

Abstract

Decorin (DCN) is primarily found in the connective tissues of various parts of the body, including the lungs, kidneys, bone tissue, aorta, and tendons. It is an important component of the extracellular matrix (ECM) and belongs to the class I small leucine-rich proteoglycans family. DCN is increasingly attracting attention due to its significant role in tumors, fibrotic diseases, and the regulation of vascular formation. Moreover, its anti-tumor properties have positioned it as a promising biomarker in the fight against cancer. Numerous studies have confirmed that DCN can exert inhibitory effects in various solid tumors, particularly in oral squamous cell carcinoma (OSCC), by activating its downstream pathways through binding with the epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition (MET) receptor, or by stabilizing and enhancing the expression of the tumor suppressor gene p53 to mediate apoptosis in cancer cells that have undergone mutation. The occurrence of OSCC is a continuous and dynamic process, encompassing the transition from normal mucosa to oral potentially malignant disorders (OPMDs), and further progressing from OPMDs to the malignant transformation into OSCC. We have found that DCN may exhibit a bidirectional effect in the progression of oral mucosal carcinogenesis, showing a trend of initial elevation followed by a decline, which decreases with the differentiation of OSCC. In OPMDs, DCN exhibits high expression and may be associated with malignant transformation, possibly linked to the increased expression of P53 in OPMDs. In OSCC, the expression of DCN is reduced, which can impact OSCC angiogenesis, and inhibit tumor cell proliferation, migration, and invasion capabilities, serving as a potential marker for predicting adverse prognosis in OSCC patients. This article reviews the current research status of DCN, covering its molecular structure, properties, and involvement in the onset and progression of oral mucosal carcinogenesis. It elucidates DCN’s role in this process and aims to offer insights for future investigations into its mechanism of action in oral mucosal carcinogenesis and its potential application in the early diagnosis and treatment of OSCC.

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Keywords

Decorin (DCN); Oral potentially malignant disorders (OPMDs); Oral leukoplakia (OLK); Oral lichen planus (OLP); Oral submucous fibrosis; Oral erythroplakia (OEL); Oral squamous cell carcinoma (OSCC)

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