Open Access

ARTICLE

A novel prognostic scoring model based on cuproptosis identifies COMMD1 as a novel therapy target for liver hepatocellular carcinoma

KE TIAN¹, ZHIPENG LI², XIANGYU ZHAI^2,3, HUAXIN ZHOU², HUI YAO^1,*

1 General Surgery Department 2, The No. 2 People’s Hospital of Lanzhou, Lanzhou, 730030, China
2 The Hepatobiliary Surgery Department, The Second Hospital of Shandong University, Jinan, 250000, China
3 Organ Transplant Department, Qilu Hospital of Shandong University, Jinan, 250000, China

* Corresponding Author: HUI YAO. Email:

(This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)

Oncology Research 2025, 33(3), 617-630. https://doi.org/10.32604/or.2024.049772

Received 17 January 2024; Accepted 16 May 2024; Issue published 28 February 2025

Abstract

Background: Primary liver cancer poses a significant global health burden, with projections indicating a surpassing of one million cases by 2025. Cuproptosis, a copper-dependent mechanism of cell death, plays a crucial role in the pathogenesis, progression, and prognosis of various cancers, including hepatocellular carcinoma (HCC). Purpose: This study aimed to develop a prognostic model for HCC based on cuproptosis-related genes, utilizing clinical data and gene expression profiles from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Materials and Methods: Clinical features and gene expression data of HCC patients were collected from publicly available databases. Patients from TCGA were randomly divided into training and testing sets, and Lasso Cox regression was applied to develop a predictive model using cuproptosis-related genes. Results: The analysis identified Copper Metabolism Domain Containing 1 (COMMD1) as a potential prognostic marker for HCC, with deletion of this gene impacting disease progression. Cellular functional experiments validated the role of COMMD1 in HCC. Conclusions: COMMD1 emerges as a promising candidate for HCC treatment, with implications for prognosis prediction and therapeutic targeting.

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Keywords

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Supplementary Material

Supplementary Material File

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