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CircRNA circ_0015278 induces ferroptosis in lung adenocarcinoma through the miR-1228/P53 axis

LIANGJIANG XIA1, GUANGBIN LI2, QINGWU ZHOU3, YU FENG2,*, HAITAO MA2,*
1 Department of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215006, China
2 Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China
3 The First Clinical Medical College of Nanchang University, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China
* Corresponding Author: YU FENG. Email: email; HAITAO MA. Email: email

Oncology Research https://doi.org/10.32604/or.2024.050835

Received 19 February 2024; Accepted 11 May 2024; Published online 26 June 2024

Abstract

Background: Circular RNAs play an important role in regulating lung adenocarcinoma (LUAD). Bioinformatics analysis identified circ_0015278 as differentially expressed in LUAD. However, the biological mechanism of circ_0015278 in LUAD has not been fully clarified, especially in ferroptosis. Materials and Methods: Bioinformatics analysis was employed to explore the downstream mechanisms of Circ_0015278, subsequently confirmed by luciferase reporter assays. The impact of Circ_0015278 on cell proliferation, migration, invasion, and ferroptosis was investigated through a loss-of-function experiment. A xenotransplantation mouse model elucidated the effect of Circ_0015278 on tumour growth. Results: Circ_0015278 exhibited downregulation in LUAD. It inhibited cell proliferation, migration, and invasion while promoting ferroptosis by interacting with miR-1228 to regulate P53 expression through a competitive endogenous RNA mechanism. Moreover, circ_0015278 suppressed tumour growth in mice. Conclusions: Circ_0015278 was identified as a novel factor promoting ferroptosis in LUAD. Furthermore, it suppressed the malignant progression of LUAD through the miR-1228/P53 axis.

Keywords

Lung adenocarcinoma (LUAD); Circ_0015278; Ferroptosis; miR-1228; P53; SLC7A11

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