Open Access
ARTICLE
ENRICO CALIMAN1,2, SARA FANCELLI1,2, FEDERICO SCOLARI3, ADRIANO PASQUI4, CLARA MANNESCHI4, DANIELE LAVACCHI1, FRANCESCA MAZZONI4, FRANCESCA GENSINI5, VALERIA PASINI6, CAMILLA EVA COMIN2,7, LUCA VOLTOLINI2,8, SERENA PILLOZZI1,2,*, LORENZO ANTONUZZO1,2,4
Oncology Research, DOI:10.32604/or.2024.050161
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Background: Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients’ survival. Materials and Methods: We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes—namely ERCC1, ERCC2,… More >
Open Access
ARTICLE
MEHRSA JALALIZADEH1,#, HEVELINE RAYANE MOURA ROESCH1,#, FERNANDO KORKES2, QUOC DIEN-TRINH3, LEONARDO OLIVEIRA REIS1,4,*
Oncology Research, DOI:10.32604/or.2024.052179
Abstract Background and Aims: The Brazilian Unified Health System (Sistema Único de Saúde−SUS) is the universal public healthcare system of Brazil that maintains a nationwide database of its patients. Our primary objective was to analyze regional and temporal trends, while our secondary goal was to establish correlations between states’ health economy status and their prostate cancer (PCa) epidemiology. Methods: We analyzed Brazil’s nationwide data on prostate cancer (PCa) incidence, mortality, and care gathered between 2013 and 2021 by the Information Technology Department of SUS (DATA-SUS), updated monthly using the International Classification of Diseases (ICD-10) code. Results: In… More >
Open Access
ARTICLE
KE TIAN1, ZHIPENG LI2, XIANGYU ZHAI2,3, HUAXIN ZHOU2, HUI YAO1,*
Oncology Research, DOI:10.32604/or.2024.049772
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Background: Primary liver cancer poses a significant global health burden, with projections indicating a surpassing of one million cases by 2025. Cuproptosis, a copper-dependent mechanism of cell death, plays a crucial role in the pathogenesis, progression, and prognosis of various cancers, including hepatocellular carcinoma (HCC). Purpose: This study aimed to develop a prognostic model for HCC based on cuproptosis-related genes, utilizing clinical data and gene expression profiles from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Materials and Methods: Clinical features and gene expression data of HCC patients were collected from publicly available More >
Open Access
ARTICLE
LIANGJIANG XIA1, GUANGBIN LI2, QINGWU ZHOU3, YU FENG2,*, HAITAO MA2,*
Oncology Research, DOI:10.32604/or.2024.050835
Abstract Background: Circular RNAs play an important role in regulating lung adenocarcinoma (LUAD). Bioinformatics analysis identified circ_0015278 as differentially expressed in LUAD. However, the biological mechanism of circ_0015278 in LUAD has not been fully clarified, especially in ferroptosis. Materials and Methods: Bioinformatics analysis was employed to explore the downstream mechanisms of Circ_0015278, subsequently confirmed by luciferase reporter assays. The impact of Circ_0015278 on cell proliferation, migration, invasion, and ferroptosis was investigated through a loss-of-function experiment. A xenotransplantation mouse model elucidated the effect of Circ_0015278 on tumour growth. Results: Circ_0015278 exhibited downregulation in LUAD. It inhibited cell proliferation, More >
Open Access
CORRECTION
HUI SUN; MASANORI KAWANO*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA
Oncology Research, DOI:10.32604/or.2024.052652
Abstract This article has no abstract. More >
Open Access
ARTICLE
YOUSEF KATIB1,*, NASSER MULLA2
Oncology Research, DOI:10.32604/or.2024.052358
Abstract Background: Lung cancer (LC) is one of the most common neoplastic diseases and a leading cause of death in Saudi Arabia. Its incidence in Saudi Arabia has increased by more than 3% within two decades. Our study aimed to describe the epidemiological and genetic landscapes of LC in Al-Madinah city in Saudi Arabia. Methods: A retrospective analysis was conducted on the medical records of 65 patients diagnosed with lung cancer between 2015 and 2021 at a single medical oncology center in Al-Madinah city of Saudi Arabia. Results: The mean patients’ age was 59.2 years, with 50… More >
Open Access
REVIEW
DIMITRA P. VAGELI1,2,*, PANAGIOTIS G. DOUKAS3, KERASIA GOUPOU2, ANTONIOS D. BENOS2, KYRIAKI ASTARA2,4, KONSTANTINA ZACHAROULI2, SOTIRIS SOTIRIOU5, MARIA IOANNOU2
Oncology Research, DOI:10.32604/or.2024.052130
Abstract Glioblastoma multiforme (GBM) is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular proliferation. Hypoxic conditions in the tissue microenvironment are considered a pivotal player leading tumor progression. Specifically, hypoxia is known to activate inducible factors, such as hypoxia-inducible factor 1alpha (HIF-1α), which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators, such as the vascular endothelial growth factor (VEGF). Here, we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data, as potential biomarkers of GBM prognosis… More >
Open Access
ARTICLE
MAHDI ABDOLI SHADBAD1, BEHZAD BARADARAN2,*
Oncology Research, DOI:10.32604/or.2024.051569
Abstract Background: Glioblastoma remains a highly invasive primary brain malignancy with an undesirable prognosis. Growing evidence has shed light on the importance of microRNAs (miRs), as small non-coding RNAs, in tumor development and progression. The present study leverages the in-silico and in-vitro techniques to investigate the significance of hsa-miR-181a-5p and the underlying hsa-miR-181a-5p-meidated signaling pathway in glioblastoma development. Methods: Bioinformatic studies were performed on GSE158284, GSE108474 (REMBRANDT study), TCGA-GTEx, CCLE, GeneMANIA, Reactome, WikiPathways, KEGG, miRDB, and microT-CDS to identify the significance of hsa-miR-181a-5p and its underlying target. Afterward, the U373 cell line was selected and transfected with… More >
Open Access
ARTICLE
ZHENGYANG ZHOU1,#, LEI QIAO1,#, TONGTONG WANG1, WEN PAN1, JINGJING DUAN1, HAIYANG ZHANG2, TING DENG1, YI BA1,*, YI HE1,*
Oncology Research, DOI:10.32604/or.2024.050431
Abstract Background: Patients with gastric cancer (GC) are prone to lymph node metastasis (LNM), which is an important factor for recurrence and poor prognosis of GC. Nowadays, more and more studies have confirmed that exosomes can participate in tumor lymphangiogenesis. An in-depth exploration of the pathological mechanism in the process of LNM in GC may provide effective targets and improve the diagnosis and treatment effect. Materials and Methods: We used sequencing analysis of collected serum to screen out exo-miRNA related to LNM in GC. ELISA, qRT-PCR, Western Blot, RNA pull-down assay, Transwell assay, animal experiments, and other… More >
Graphic Abstract
Open Access
ARTICLE
JEN-PIN CHUANG1,2,3, HSIANG-LIN TSAI4,5, WEI-CHIH SU4,6,7, PO-JUNG CHEN4,6, CHING-WEN HUANG4,5, TSUNG-KUN CHANG4,6,7, YEN-CHENG CHEN4,6, CHING-CHUN LI4,8, YUNG-SUNG YEH4,9,10, TZU-CHIEH YIN4,5,11, JAW-YUAN WANG4,5,6,12,13,*
Oncology Research, DOI:10.32604/or.2024.052098
Abstract Background: The pTNM staging system is widely recognized as the most effective prognostic indicator for cancer. The latest update of this staging system introduced a new pathological staging system (ypTNM) for patients receiving neoadjuvant chemoradiotherapy (NACRT). However, whether the prognostic value of the ypTNM staging system for rectal cancer is similar to that of the pTNM staging system remains unclear. This study was conducted to compare the ypTNM and pTNM staging systems in terms of their prognostic value for patients with nonmetastatic rectal cancer undergoing proctectomy. Material and Methods: This study was conducted at a large teaching… More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055039
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055037
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055036
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055035
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055034
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055033
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055032
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055031
Abstract This article has no abstract. More >
Open Access
RETRACTION
Oncology Research Editorial Office
Oncology Research, DOI:10.32604/or.2024.055030
Abstract This article has no abstract. More >
Open Access
REVIEW
MEIR DJALDETTI*
Oncology Research, DOI:10.32604/or.2024.049745
Abstract Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells to produce pro-inflammatory cytokines, including IL-1β, IL-6, IL-1ra and TNFα. Considering the close association between chronic inflammation and cancer development, RSV’s immunomodulatory properties are one way by which the polyphenol may inhibit cancer initiation, proliferation, neovascularization, and migration. Resveratrol influences the generation of microtumor environment which is one of the key factors in cancer progress. In addition to immunomodulation, RSV inhibits cancer development by expressing anti-oxidant effects, causing cell cycle… More >
Graphic Abstract
Open Access
ARTICLE
TIANYUN ZHU1,2,#, CUNYAN ZHAO1,2,#, RUI GONG1,2, AO QIAN1, XIAOSHU WANG1, FANGHUI LU2, GANG HUO1, LIANGJUN QIAO3, SONG CHEN1,*
Oncology Research, DOI:10.32604/or.2024.050794
Abstract Background: PLK3, which played an important role in cell cycle progression and stress response, was identified as highly expressed in various carcinomas. However, the functions, molecular characteristics, and prognostic value of PLK3 in glioma remained unexplored. Methods: We analyzed PLK3 expression in glioma samples from multiple databases. Both overexpression and knockdown of Plk3 were performed to investigate tumor cell growth in glioma, and the transplanted glioma mouse model demonstrated the role of Plk3 on tumor progression. Immunohistochemistry was conducted to detect PLK3 expression and immune cell infiltration. The trans-well assay for PLK3 on the immune… More >
Open Access
ARTICLE
CHUAN JIANG1,2, CHUNLEI LIU1,3, XI YAO1,3, JINGYA SU1,2, WEI LU1,3, ZHENGBO WEI3,*, YING XIE1,2,*
Oncology Research, DOI:10.32604/or.2024.052244
Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer globally, with chemoresistance posing a major challenge in treatment outcomes. The efficacy of the commonly used chemotherapeutic agent, cisplatin, is diminished in patients with poor prognoses. Methods: Various bioinformatics databases were utilized to examine Carboxylesterase 1 (CES1) gene expression, clinicopathologic features, patient survival analysis, and gene function. An organoid model of HNSCC was established, along with the induction of drug-resistant HNSCC in the organoid model. CES1 expression was assessed using qRT-PCR and Western Blot, and differential markers were identified through transcriptome… More >
Open Access
REVIEW
SIDDAVARAM NAGINI1, PRATHAP REDDY KALLAMADI2, KRANTHI KIRAN KISHORE TANAGALA3, GEEREDDY BHANUPRAKASH REDDY2,*
Oncology Research, DOI:10.32604/or.2024.049918
Abstract Aldo-keto reductases (AKRs) are a superfamily of enzymes that play crucial roles in various cellular processes, including the metabolism of xenobiotics, steroids, and carbohydrates. A growing body of evidence has unveiled the involvement of AKRs in the development and progression of various cancers. AKRs are aberrantly expressed in a wide range of malignant tumors. Dysregulated expression of AKRs enables the acquisition of hallmark traits of cancer by activating oncogenic signaling pathways and contributing to chemoresistance. AKRs have emerged as promising oncotherapeutic targets given their pivotal role in cancer development and progression. Inhibition of aldose reductase… More >
Open Access
ARTICLE
SHUO YU, MIN WANG, XU LI, XINGJUN GUO, RENYI QIN*
Oncology Research, DOI:10.32604/or.2024.046774
（This article belongs to the Special Issue: Advances in Cancer Therapeutics)
Abstract Background: Circular RNAs (circRNAs) play a pivotal role in the development and advancement of various cancer types. However, the involvement of circ-PAN3 in hepatocellular carcinoma (HCC) is not well understood. To shed light on this, we conducted a comprehensive study through biochemistry, cell biology, molecular biology, and bioinformatics techniques to investigate the role of circ-PAN3 and its associated pathway in the progression of HCC. Methods: Cell Counting Kit-8 (CCK-8) assay and colony formation assay were utilized to evaluate cell proliferation; Quantitative real-time PCR (RT-qPCR) and Western blot were adopted for assessing mRNA and protein expression;… More >
Open Access
ARTICLE
HAIYING PANG1,#, FENGBO WU1,#, YU ZHANG1, NAN ZHANG2, CHUNTING WANG1, QIU LI1, GU HE1,*, PENG ZHANG3,*
Oncology Research, DOI:10.32604/or.2024.043948
（This article belongs to the Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Background: EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family. EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues, where it may play a role in either promoting or inhibiting tumor growth. This study aimed to investigate the expression level, biological functions, and molecular mechanisms of EMP2 in liver cancer. Methods: we analyzed the mRNA expression levels of EMPs family genes in hepatocellular carcinoma (HCC) tissues and normal liver tissues based on the TCGA database and immunohistochemical analysis of tissue microarrays. Subsequently, we constructed HCC cell… More >
Graphic Abstract
Open Access
REVIEW
GERHARD HAMILTON*, MARIE-THERESE EGGERSTORFER, SANDRA STICKLER
Oncology Research, DOI:10.32604/or.2024.051653
Abstract The Kirsten rat sarcoma virus—son of sevenless 1 (KRAS-SOS1) axis drives tumor growth preferentially in pancreatic, colon, and lung cancer. Now, KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS. However, the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%, lasting for a mean period of 8 months. One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras (PROTACs), which… More >
Graphic Abstract
Open Access
VIEWPOINT
STEPHEN E. LANGABEER*
Oncology Research, DOI:10.32604/or.2024.051218
Abstract Hairy cell leukemia (HCL) is an uncommon mature B-cell malignancy characterized by a typical morphology, immunophenotype, and clinical profile. The vast majority of HCL patients harbor the canonical BRAF V600E mutation which has become a rationalized target of the subsequently deregulated RAS-RAF-MEK-MAPK signaling pathway in HCL patients who have relapsed or who are refractory to front-line therapy. However, several HCL patients with a classical phenotype display non-canonical BRAF mutations or rearrangements. These include sequence variants within alternative exons and an oncogenic fusion with the IGH gene. Care must be taken in the molecular diagnostic work-up of patients More >
Open Access
REVIEW
YUN WANG1, XIAOJIANG LI2, DALONG LIU2, ZHIFENG WANG3, JICHEN XIA4, LIJUN WANG5, XUDONG ZHANG6,*
Oncology Research, DOI:10.32604/or.2024.043482
Abstract Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging… More >
Graphic Abstract
Open Access
REVIEW
ANA S. CVETANOVIC1,2,*, MATTEO LAMBERTINI3,4, KEVIN PUNIE5, GORANA G. MATOVINA BRKO6, NIKOLA D. ZIVKOVIC7,8, MAJA J. POPOVIC6,9, MARIJANA M. MILOVIC KOVACEVIC10, LAZAR S. POPOVIC6,9
Oncology Research, DOI:10.32604/or.2024.049743
Abstract Oncofertility is an extremely significant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but significantly contributes to preserving life quality. The effect of chemotherapy can range from minimal effects to complete ovarian atrophy. Limited data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and fertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy decreases the gonadotoxic effect of chemotherapy, thereby diminishing the chance of developing premature ovarian insufficiency (POI).… More >
Graphic Abstract
Open Access
REVIEW
SNJEŽANA KAŠTELAN1,2, ANA DIDOVIĆ PAVIČIĆ3, DARIA PAŠALIĆ4, TAMARA NIKUŠEVA-MARTIĆ5, SAMIR ČANOVIĆ3,7, PETRA KOVAČEVIĆ1,6,*, SUZANA KONJEVODA3,7
Oncology Research, DOI:10.32604/or.2024.048437
Abstract Uveal and conjunctival melanomas are relatively rare tumors; nonetheless, they pose a significant risk of mortality for a large number of affected individuals. The pathogenesis of melanoma at different sites is very similar, however, the prognosis for patients with ocular melanoma remains unfavourable, primarily due to its distinctive genetic profile and tumor microenvironment. Regardless of considerable advances in understanding the genetic characteristics and biological behaviour, the treatment of uveal and conjunctival melanoma remains a formidable challenge. To enhance the prospect of success, collaborative efforts involving medical professionals and researchers in the fields of ocular biology… More >
Graphic Abstract
Open Access
ARTICLE
QI LV1,#, GANGMIN WANG2,#, YI HONG1, TIANYI ZHU1, SHUANG QIN1, SAIFEI SUN1, YUTING WANG1, YAOHUA LIU1, QING ZHANG1, CHUNHUI MA3,*, PEIJUN WANG1,*
Oncology Research, DOI:10.32604/or.2024.047698
Abstract Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and developing practical countermeasures for sunitinib resistance in RCC is desirable. In previous studies, we found that circAGAP1 expression was significantly upregulated in clear cell RCC (ccRCC) and was strongly associated with poor prognosis. However, the role of circAGAP1 in sunitinib resistance in ccRCC remains unclear. Methods: We used public databases for bioinformatics analysis to identify the binding targets of circAGAP1. Additionally, the effects of circAGAP1 on the proliferation, clonogenesis, apoptosis, and migration of ccRCC cells were… More >
Graphic Abstract
Open Access
ARTICLE
LIANG HE1,2, WEI HAN1,3, KAI YUE1, XUDONG WANG1,*
Oncology Research, DOI:10.32604/or.2024.047382
Abstract Background: Thyroid cancer (THCA) is the most common malignant tumor in endocrine system and the incidence has been increasing worldwide. And the number of patients dying from THCA has also gradually risen because the incidence continues to increase, so the mechanisms related to effective targets is necessary to improve the survival. This study was to preliminarily investigate the effects of the COL4A2 gene on the regulation of thyroid cancer (THCA) cell proliferation and the associated pathways. Methods: Bioinformatics analysis revealed that COL4A2 was closely associated with cancer development. COL4A2 expression in THCA tissues was analyzed using… More >
Open Access
ARTICLE
YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN*
Oncology Research, DOI:10.32604/or.2024.045564
Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More >
Graphic Abstract
Open Access
ARTICLE
TATIANA KURILO*, REBECCA D. PENTZ
Oncology Research, DOI:10.32604/or.2024.050266
Abstract Background: Rural patients have poor cancer outcomes and clinical trial (CT) enrollment compared to urban
patients due to attitudinal, awareness, and healthcare access differential. Knowledge of cancer survival disparities and CT
enrollment is important for designing interventions and innovative approaches to address the stated barriers. The study
explores the potential disparities in cancer survival rates and clinical trial enrollments in rural and urban breast and lung
cancer patients. Our hypotheses are that for both cancer types, urban cancer patients will have longer 5-year survival rates
and higher enrollment rates in clinical trials than those in rural… More >
Open Access
ARTICLE
JINXIA CHEN1,2,3,#, SULI DAI1,2,#, GENG ZHANG4,5, SISI WEI1,2, XUETAO ZHAO3, YANG ZHENG1,2, YAOJIE WANG1,2, XIAOHAN WANG1,2, YUNJIANG LIU4,5,*, LIANMEI ZHAO1,2,*
Oncology Research, DOI:10.32604/or.2024.049348
（This article belongs to the Special Issue: Recent Advances in Cancer Pharmacology)
Abstract Background: Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer characterized by a high rate of metastasis, poor prognosis, and lack of efficient therapies. KBU2046, a small molecule inhibitor, can inhibit cell motility in malignant tumors, including breast cancer. However, the specific targets and the corresponding mechanism of its function remain unclear. Methods: In this study, we employed (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium) (MTS) assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro. RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.… More >
Graphic Abstract
Open Access
ARTICLE
ROSSANA RONCATO1,2, JERRY POLESEL3, FEDERICA TOSI4,5,*, ELENA PERUZZI1,*, ERIKA BRUGUGNOLI6, CLAUDIA LAURIA PANTANO7, MARIA FURFARO8, FILIPPO DI GIROLAMO9,10, ALESSANDRO NANI11, ARIANNA PANI4, NOEMI MILAN1, ELENA DE MATTIA1, ANDREA SARTORE-BIANCHI4,5, ERIKA CECCHIN1
Oncology Research, DOI:10.32604/or.2024.049181
Abstract Background: Treatment of metastatic colorectal cancer (mCRC) includes resection of liver metastases (LM), however, no validated biomarker identifies patients most likely to benefit from this procedure. This meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC (i.e., RAS, BRAF, SMAD4, PIK3CA) as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM resection. Methods: A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM, stratified according to RAS,… More >
Graphic Abstract
Open Access
ARTICLE
LEI WANG1, XIANJIN XIE2,*
Oncology Research, DOI:10.32604/or.2024.048562
Abstract Background: To investigate STIL centriolar assembly protein (STIL)’s role and prognostic significance in lung adenocarcinoma (LUAD) progression, we examined STIL and E2 promoter binding factor 1 (E2F1) expressions and their impacts on LUAD prognosis using Gene Expression Profiling Interactive Analysis (GEPIA). Methods: Functional assays including CCK-8, wound-healing, 5-ethynyl-2-deoxyuridine (EdU), Transwell assays, and flow cytometry, elucidated STIL and E2F1’s effects on cell viability, proliferation, apoptosis, and migration. GSEA identified potential pathways, while metabolic assays assessed glucose metabolism. Results: Our findings reveal that STIL and E2F1 are overexpressed in LUAD, correlating with adverse outcomes. It enhances cell proliferation, migration, and More >
Open Access
ARTICLE
WEI ZHANG1,3,#, WEICHENG WANG1,#, RUI WANG1, XIAO HAN1, LIJUN ZHU1, WENJIE GUO2,*, YANHONG GU1,*
Oncology Research, DOI:10.32604/or.2024.050047
Abstract Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been
approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread
adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown
potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and
mechanisms of fruquintinib combined with venetoclax in treating CRC. Methods and Materials: We developed a
colon cancer mouse model with the CT26 cell line to demonstrate fruquintinib and venetoclax’s efficacy against
tumors. Then we… More >
Graphic Abstract
Open Access
ARTICLE
CANCAN HE1,2,*, TINGTING ZHANG3, WEI XIONG4, SHENGYU WANG5, XIN SUN6
Oncology Research, DOI:10.32604/or.2024.049757
Abstract Background: The outcomes of pediatric patients with acute lymphoblastic leukemia (ALL) remain far less than
favorable. While apigenin is an anti-cancer agent, studies on the mechanism by which it regulates ALL cell cycle
progression are inadequate. Ferroptosis and AMP-activated protein kinase (AMPK) signaling are important processes
for ALL patients. However, it remains unclear whether apigenin works by affecting AMPK and apoptosis. Materials
and Methods: SUP-B15 and T-cell Jurkat ALL cells were treated with apigenin, and cell viability and apoptosis were
measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and terminal deoxynucleotidyl
transferase dUTP nick end labeling (TUNEL) assays, respectively. The… More >
Open Access
ARTICLE
YI LI1, TIANYI WANG1, HAORAN DING1, SHIYONG ZHUANG1, XIAOBO DAI1, BING YAN1,2,*
Oncology Research, DOI:10.32604/or.2024.048191
Abstract Background: Oral cancer, a malignancy that is prevalent worldwide, is often diagnosed at an advanced stage. MicroRNAs (miRNAs) in circulating exosomes have emerged as promising cancer biomarkers. The role of miRNA let-7c-5p in oral cancer remains underexplored, and its potential involvement in tumorigenesis warrants comprehensive investigation. Methods: Serum samples from 30 patients with oral cancer and 20 healthy controls were used to isolate exosomes and quantify their RNA content. Isolation of the exosomes was confirmed through transmission electron microscopy. Quantitative PCR was used to assess the miRNA profiles. The effects of let-7c-5p and TAGLN overexpression on… More >
Open Access
ARTICLE
SHIQIN JIANG1,#, YICHUN TANG2,#, FENG MA3, YUCHUN NIU4,*, LEI SUN5,*
Oncology Research, DOI:10.32604/or.2024.046895
Abstract Background: Small cell lung cancer (SCLC) is commonly recognized as the most fatal lung cancer type. Despite substantial advances in immune checkpoint blockade therapies for treating solid cancers, their benefits are limited to a minority of patients with SCLC. Objective: In the present study, novel indicators for predicting the outcomes and molecular targets for SCLC treatment were elucidated. Methods: We conducted bioinformatics analysis to identify the key genes associated with tumor-infiltrating lymphocytes in SCLC. The functional role of the key gene identified in SCLC was determined both in vitro and in vivo. Results: A significant correlation was observed… More >
Open Access
ARTICLE
YUAN YIN1, ZHENGYIN WANG1, YUJIE HU1, JIA WANG1, YI WANG2,*, QUN LU1,*
Oncology Research, DOI:10.32604/or.2024.048007
Abstract Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation. Therefore, it is gaining increasing attention due to its safe and pharmacological applications. In this study, we investigated the role of CA in inhibiting the Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer and activator of transcription-3 (STAT-3) mediated suppression of the proliferation signaling in human prostate cancer cells. Materials and Methods: The role of CA in proliferation and colony formation abilities was studied using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and colony formation assays. Tumour cell death and cell cycle arrest were… More >
Open Access
ARTICLE
FEI CHU1, KAI TONG1, XIANG GU1, MEI BAO1, YANFEN CHEN1, BIN WANG2, YANHUA SHAO1, LING WEI1,*
Oncology Research, DOI:10.32604/or.2024.048287
Abstract Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in
many biological processes of the human body. Tumor cells take up a large amount of glutamine to meet their rapid
proliferation requirements, which is supported by the upregulation of glutamine transporters. Targeted inhibition of
glutamine transporters effectively inhibits cell growth and proliferation in tumors. Among all cancers, digestive system
malignant tumors (DSMTs) have the highest incidence and mortality rates, and the current therapeutic strategies for
DSMTs are mainly surgical resection and chemotherapy. Due to the relatively More >
Open Access
ARTICLE
YUSHI YANG1,#, CHUJIAO HU2,#, SHAN LEI3, XIN BAO3, ZHIRUI ZENG3,*, WENPENG CAO4,*
Oncology Research, DOI:10.32604/or.2024.046191
（This article belongs to the Special Issue: Multi-Omics Approaches for Precision Medicine)
Abstract Background: The heterogeneity of prognosis and treatment benefits among patients with gliomas is due to tumor microenvironment characteristics. However, biomarkers that reflect microenvironmental characteristics and predict the prognosis of gliomas are limited. Therefore, we aimed to develop a model that can effectively predict prognosis, differentiate microenvironment signatures, and optimize drug selection for patients with glioma. Materials and Methods: The CIBERSORT algorithm, bulk sequencing analysis, and single-cell RNA (scRNA) analysis were employed to identify significant cross-talk genes between M2 macrophages and cancer cells in glioma tissues. A predictive model was constructed based on cross-talk gene expression, and… More >
Open Access
ARTICLE
LICHEN XU1,2, PAN ZHANG3,*, GUIQI ZHANG2, ZHAOLIANG SHEN4, XIZHUANG BAI1,3,*
Oncology Research, DOI:10.32604/or.2024.047704
Abstract Background: Osteosarcoma (OS), recognized as the predominant malignant tumor originating from bones, necessitates an in-depth comprehension of its intrinsic mechanisms to pinpoint novel therapeutic targets and enhance treatment methodologies. The role of fat mass and obesity-associated (FTO) in OS, particularly its correlation with malignant traits, and the fundamental mechanism, remains to be elucidated. Materials and Methods: 1. The FTO expression and survival rate in tumors were analyzed. 2. FTO in OS cell lines was quantified utilizing western blot and PCR. 3. FTO was upregulated and downregulated separately in MG63. 4. The impact of FTO on the… More >
Open Access
ARTICLE
WEN YANG, BIN TANG, DAN XU, WENXIU YANG*
Oncology Research, DOI:10.32604/or.2024.050036
Abstract Background: The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma (DLBCL) has been reported previously. However, the detailed mechanisms of CCR7 in DLBCL, particularly regarding its interaction with lenalidomide treatment, are not fully understood. Methods: Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups. Immunohistochemical data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of DLBCL. Furthermore, in vitro and in vivo experiments were conducted to clarify the… More >
Graphic Abstract
Open Access
ARTICLE
XIUWANG WEI1, JIANBO LIANG1, HUANWEN HUANG1, DAMING YANG1, XINXIN WANG1, XIUJIA WANG1, CHANGSHENG CHEN1, KAIQIANG LI1, TAISEN PANG1, BIN HU1, FENGNING WU2,*
Oncology Research, DOI:10.32604/or.2024.048054
Abstract Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear. Materials and Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in vivo. Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells. In vitro, shTMED3 treatment suppressed the proliferation, invasion, and migration and promoted the apoptosis of DU145 cells. Additionally, the Kyoto Encyclopedia… More >
Open Access
REVIEW
ZHENGYI WANG1,*, LIANG ZHOU1, XIAOYING WU2
Oncology Research, DOI:10.32604/or.2024.048564
Abstract Chimeric antigen receptor T-cesll therapy (CAR–T) has achieved groundbreaking advancements in clinical application, ushering in a new era for innovative cancer treatment. However, the challenges associated with implementing this novel targeted cell therapy are increasingly significant. Particularly in the clinical management of solid tumors, obstacles such as the immunosuppressive effects of the tumor microenvironment, limited local tumor infiltration capability of CAR–T cells, heterogeneity of tumor targeting antigens, uncertainties surrounding CAR–T quality, control, and clinical adverse reactions have contributed to increased drug resistance and decreased compliance in tumor therapy. These factors have significantly impeded the widespread More >
Graphic Abstract
Open Access
ARTICLE
MING ZHUANG, XUE ZHANG, LU LI, LIMING WEN, JIAMIN QIN*
Oncology Research, DOI:10.32604/or.2024.046170
Abstract Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance to sorafenib in the chemotherapy of HCC is a common and significant issue that profoundly impacts clinical treatment. While several members of the transmembrane (TMEM) protein family have been implicated in the occurrence and progression of HCC, the association between TMEM39b and HCC remains unexplored. This study revealed a significant overexpression of TMEM39b in HCC, which correlated with a poor prognosis. Subsequent investigation revealed that RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis in HCC, and knocking down the expression of TMEM39b significantly decreased its More >
Open Access
ARTICLE
WEI JIANG1, MEI ZHOU2,*
Oncology Research, DOI:10.32604/or.2024.043423
（This article belongs to the Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Multiple myeloma (MM) is a plasma cell malignancy and remains incurable as it lacks effective curative approaches; thus, novel therapeutic strategies are desperately needed. The study aimed to explore the therapeutic role of dihydromyricetin (DHM) in MM and explore its mechanisms. Human MM and normal plasma samples, human MM cell lines, and normal plasma cells were used for in vitro experiments. Cell counting kit-8 (CCK-8), flow cytometry, and trans-well assays were performed for the assessment of cell viability, apoptosis, migration, and invasion, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to assess the mRNA expression… More >
Graphic Abstract
Open Access
ARTICLE
HUI ZHOU#, ZHENGYU YU#, JING XU, ZHONGWANG WANG, YALI TAO, JINJIN WANG, PEIPEI YANG, JINRONG YANG*, TING NIU*
Oncology Research, DOI:10.32604/or.2024.048138
Abstract Background: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase
complex (PDC), a rate-limiting enzyme complex, that can participate in either glycolysis or the tricarboxylic acid
cycle (TCA). However, the pathogenesis is not fully understood. We aimed to perform a more systematic and
comprehensive analysis of DLAT in the occurrence and progression of tumors, and to investigate its function in
patients’ prognosis and immunotherapy. Methods: The differential expression, diagnosis, prognosis, genetic and
epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell
analysis, and drug response across cancers were conducted based on multiple computational tools.… More >
Graphic Abstract
Open Access
ARTICLE
RONG LIU1,#, SHENG LI2,#, SITU XIONG2, FUCUN ZHENG2, XIANGPENG ZHAN2, JIN ZENG2, BIN FU2, SONGHUI XU2, SHAOXING ZHU1,*, RU CHEN1,*
Oncology Research, DOI:10.32604/or.2024.050851
Abstract EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. The gene’s immune relevance was explored through analyses of the tumor microenvironment (TME), Tumor Immune Single-cell Hub (TISCH), immune checkpoints, and immunotherapy sensitivity. Our results indicate that EVI2A expression is upregulated in KIRC, showing correlations with tumor grade and T/N/M stage. EVI2A demonstrates high… More >
Open Access
ARTICLE
GENGYUN SUN1,*, YIPING ZHENG1,2, JIANFENG CAI2, JIE GAO2, LIE DONG2, XIANGBIN ZHANG2, YINGHUI HUANG2,*
Oncology Research, DOI:10.32604/or.2024.047626
（This article belongs to the Special Issue: Long noncoding RNAs as Tumorigenic Drivers and Therapeutic Targets)
Abstract Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear. LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the expression of… More >
Graphic Abstract
Open Access
ARTICLE
YUZHI LIU1,#, EVELYNE BISCHOF2,#, ZHIQIN CHEN1, JIAHUAN ZHOU3, BEI ZHANG4, DING ZHANG4, YONG GAO1,*, MING QUAN1,*
Oncology Research, DOI:10.32604/or.2024.047309
Abstract Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes, tumor mutational burden, microsatellite instability, and programmed death ligand 1 (PD-L1) expression. Among 2454 CRC patients, 85 cases (3.46%) exhibited ERBB2 amplification, and 55 cases (2.24%) carried ERBB2 mutation. p.R678Q (28%),… More >
Graphic Abstract
Open Access
ARTICLE
ZHOUYANG CHENG1,#, YUCHEN HUA2,#, YANG CAO3, JUN QIN1,*
Oncology Research, DOI:10.32604/or.2024.042281
（This article belongs to the Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies. Studies have shown that the lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as a tumor promoter in various malignancies, while its function in GC has yet to be characterized. Herein, we discovered that SNHG4 was overexpressed in GC tissues and cell lines,… More >
Open Access
ARTICLE
YUQIN YIN1,2,#, YU WU1,#, HONGLIANG HUANG1,2, YINGYING DUAN1,2, ZHONGWEN YUAN1,2, LIHUI CAO1,2, JINJIN YING1,2, YONGHENG ZHOU3,*, SENLING FENG1,2,*
Oncology Research, DOI:10.32604/or.2024.048778
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Background: Polymethoxylated flavones (PMFs) are compounds present in citrus peels and other Rutaceae plants, which exhibit diverse biological activities, including robust antitumor and antioxidant effects. However, the mechanism of PMFs in reversing drug resistance to colon cancer remains unknown. In the present study, we aimed to investigate the potential connection between the aerobic glycolysis-ROS-autophagy signaling axis and the reversal of PTX resistance in colon cancer by PMFs. Methods: MTT Cell viability assay and colony formation assay were used to investigate the effect of PMFs combined with PTX in reversing HCT8/T cell resistance ex vivo; the mRNA… More >
Graphic Abstract
Open Access
REVIEW
WEIGANG XIU1,#, XINGYU LIU1,2,#, KAIXIN HU1,2, QIN ZHANG3,*, HUASHAN SHI4,*
Oncology Research, DOI:10.32604/or.2024.047933
（This article belongs to the Special Issue: Metabolism of Cancer Cells and Immune Cells: A Balancing Action for Cancer Immunotherapy)
Abstract Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the More >
Open Access
ARTICLE
RUIFANG LI1, XINRONG NAN2,*, MING LI3,*, OMAR RAHHAL3
Oncology Research, DOI:10.32604/or.2024.046965
Abstract Background: Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. Objective: We aimed to assess the pan-cancer expression profile of FAP, its molecular function, and its potential role in head and neck squamous cell carcinoma (HNSC). Methods: We analyzed gene expression, survival status, immune infiltration, and molecular functional pathways of FAP in The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) tumors. Furthermore, to elucidate the role of FAP in HNSC, we performed proliferation, migration, and invasion assays post-FAP… More >
Open Access
ARTICLE
HAIQING HU1,#,*, HAO YANG2,#, SHUAISHUAI FAN3, XUE JIA3, YING ZHAO3, HONGRUI LI3
Oncology Research, DOI:10.32604/or.2024.044174
Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >
Open Access
ARTICLE
ZIYONG LIU1,#, TAO MA1,#, JINFANG LI2, WEI REN1,*, ZHIXIN ZHANG1,*
Oncology Research, DOI:10.32604/or.2024.048315
Abstract Background:: Interleukin 13 receptor subunit alpha 2 (IL13RA2) plays an essential role in the progression of many cancers. However, the role of IL13RA2 in infantile haemangioma (IH) is still unknown. Materials and Methods:: IL13RA2 expression in IH tissues was analyzed using western blot, qRT-PCR, and immunofluorescence. The role of IL13RA2 in haemangioma-derived endothelial cells (HemECs) was determined following knockdown or overexpression of IL13RA2 using CCK-8, colony formation, apoptosis, wound healing, tubule formation, Transwell, and western blot. Results:: IL13RA2 expression was upregulated in IH tissues. IL13RA2 overexpression promoted proliferation, migration, and invasion of HemECs and induced glycolysis, More >
Open Access
ARTICLE
YE ZHANG1, YANAN LIANG2, YAN WU2, LIWEN SONG2, ZUWANG ZHANG2,*
Oncology Research, DOI:10.32604/or.2024.030945
Abstract Background: Papillary thyroid cancer (PTC) is the most prevalent histological type of differentiated thyroid malignancy. Circular RNAs (circRNAs) have been implicated in the pathogenesis and progression of various cancers. circTIAM1 (hsa_circ_0061406) is a novel circRNA with aberrant expression in PTC. However, its functional roles in PTC progression remain to be investigated. Methods: The expression levels of circTIAM1 in the PTC and the matched para-cancerous tissues were detected by quantitative real-time reverse-transcription PCR (qRT-PCR). The subcellular localization of circTIAM1 was examined by fluorescence in-situ hybridization (FISH). Kaplan-Meier plot was used to analyze the association of clinicopathological features… More >
Open Access
ARTICLE
PEILING WU#, LIFANG ZHAO#, HONGYAN ZHANG, YUEYAN LOU, DONGFANG CHEN, SHAN XUE, XUEQING LIU*, HANDONG JIANG*
Oncology Research, DOI:10.32604/or.2024.047490
Abstract The pro-oncogenic effects of NCAPD2 have been extensively studied across various tumor types; however, its precise role within the context of lung adenocarcinoma (LUAD) remains elusive. This study aims to elucidate the biological functions of NCAPD2 in LUAD and unravel the underlying mechanistic pathways. Utilizing bioinformatics methodologies, we explored the differential expression of NCAPD2 between normal and tumor samples, along with its correlations with clinical-pathological characteristics, survival prognosis, and immune infiltration. In the TCGA-LUAD dataset, tumor samples demonstrated significantly elevated levels of NCAPD2 expression compared to normal samples (p < 0.001). Clinically, higher NCAPD2 expression was… More >
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