Open Access
ARTICLE
MAHER KURDI1,*, ALAA ALKHOTANI2, ABDULRAHMAN SABBAGH3, EYAD FAIZO4, AHMED I. LARY5, AHMED K. BAMAGA6, MAJID ALMANSOURI7, BADR HAFIZ8, THAMER ALSHARIF9, SALEH BAEESA8
Oncology Research, DOI:10.32604/or.2024.051112
Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype glioblastomas (n… More >
Graphic Abstract
Open Access
ARTICLE
HUI ZHOU#, ZHENGYU YU#, JING XU, ZHONGWANG WANG, YALI TAO, JINJIN WANG, PEIPEI YANG, JINRONG YANG*, TING NIU*
Oncology Research, DOI:10.32604/or.2024.048138
Abstract Background: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase
complex (PDC), a rate-limiting enzyme complex, that can participate in either glycolysis or the tricarboxylic acid
cycle (TCA). However, the pathogenesis is not fully understood. We aimed to perform a more systematic and
comprehensive analysis of DLAT in the occurrence and progression of tumors, and to investigate its function in
patients’ prognosis and immunotherapy. Methods: The differential expression, diagnosis, prognosis, genetic and
epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell
analysis, and drug response across cancers were conducted based on multiple computational tools. Additionally, we
validated… More >
Graphic Abstract
Open Access
ARTICLE
RONG LIU1,#, SHENG LI2,#, SITU XIONG2, FUCUN ZHENG2, XIANGPENG ZHAN2, JIN ZENG2, BIN FU2, SONGHUI XU2, SHAOXING ZHU1,*, RU CHEN1,*
Oncology Research, DOI:10.32604/or.2024.050851
Abstract EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. The gene’s immune relevance was explored through analyses of the tumor microenvironment (TME), Tumor Immune Single-cell Hub (TISCH), immune checkpoints, and immunotherapy sensitivity. Our results indicate that EVI2A expression is upregulated in KIRC, showing correlations with tumor grade and T/N/M stage. EVI2A demonstrates high diagnostic accuracy (AUC=0.906) and predicts… More >
Open Access
ARTICLE
GENGYUN SUN1,*, YIPING ZHENG1,2, JIANFENG CAI2, JIE GAO2, LIE DONG2, XIANGBIN ZHANG2, YINGHUI HUANG2,*
Oncology Research, DOI:10.32604/or.2024.047626
（This article belongs to this Special Issue: Long noncoding RNAs as Tumorigenic Drivers and Therapeutic Targets)
Abstract Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear. LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes (ATGs) in LUAD… More >
Graphic Abstract
Open Access
ARTICLE
YUZHI LIU1,#, EVELYNE BISCHOF2,#, ZHIQIN CHEN1, JIAHUAN ZHOU3, BEI ZHANG4, DING ZHANG4, YONG GAO1,*, MING QUAN1,*
Oncology Research, DOI:10.32604/or.2024.047309
Abstract Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes, tumor mutational burden, microsatellite instability, and programmed death ligand 1 (PD-L1) expression. Among 2454 CRC patients, 85 cases (3.46%) exhibited ERBB2 amplification, and 55 cases (2.24%) carried ERBB2 mutation. p.R678Q (28%), p.V8421 (24%), and p.S310F/Y (12%)… More >
Graphic Abstract
Open Access
ARTICLE
ZHOUYANG CHENG1,#, YUCHEN HUA2,#, YANG CAO3, JUN QIN1,*
Oncology Research, DOI:10.32604/or.2024.042281
（This article belongs to this Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies. Studies have shown that the lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as a tumor promoter in various malignancies, while its function in GC has yet to be characterized. Herein, we discovered that SNHG4 was overexpressed in GC tissues and cell lines, and was linked with poor… More >
Open Access
ARTICLE
YUQIN YIN1,2,#, YU WU1,#, HONGLIANG HUANG1,2, YINGYING DUAN1,2, ZHONGWEN YUAN1,2, LIHUI CAO1,2, JINJIN YING1,2, YONGHENG ZHOU3,*, SENLING FENG1,2,*
Oncology Research, DOI:10.32604/or.2024.048778
（This article belongs to this Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Background: Polymethoxylated flavones (PMFs) are compounds present in citrus peels and other Rutaceae plants, which exhibit diverse biological activities, including robust antitumor and antioxidant effects. However, the mechanism of PMFs in reversing drug resistance to colon cancer remains unknown. In the present study, we aimed to investigate the potential connection between the aerobic glycolysis-ROS-autophagy signaling axis and the reversal of PTX resistance in colon cancer by PMFs. Methods: MTT Cell viability assay and colony formation assay were used to investigate the effect of PMFs combined with PTX in reversing HCT8/T cell resistance ex vivo; the mRNA and protein levels of… More >
Graphic Abstract
Open Access
REVIEW
WEIGANG XIU1,#, XINGYU LIU1,2,#, KAIXIN HU1,2, QIN ZHANG3,*, HUASHAN SHI4,*
Oncology Research, DOI:10.32604/or.2024.047933
（This article belongs to this Special Issue: Metabolism of Cancer Cells and Immune Cells: A Balancing Action for Cancer Immunotherapy)
Abstract Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the tumor microenvironment and within tumor… More >
Open Access
ARTICLE
MARKO SKELIN1,2,3,*, BRUNA PERKOV-STIPIčIN1, SANJA VUšKOVIć4, MARINA ŠANDRK PLEHAčEK5, ANE BAšIć6, DAVID ŠARčEVIć7, MAJA ILIĆ8, IVAN KREčAK2,3,9
Oncology Research, DOI:10.32604/or.2024.048948
Abstract Background: The European Society for Medical Oncology (ESMO) guidelines are among the most comprehensive and widely used clinical practice guidelines (CPGs) globally. However, the level of scientific evidence supporting ESMO CPG recommendations has not been systematically investigated. This study assessed ESMO CPG levels of evidence (LOE) and grades of recommendations (GOR), as well as their trends over time across various cancer settings. Methods: We manually extracted every recommendation with the Infectious Diseases Society of America (IDSA) classification from each CPG. We examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer types.… More >
Open Access
REVIEW
KARAN WADHWA1, PAYAL CHAUHAN1, SHOBHIT KUMAR2, RAKESH PAHWA3,*, RAVINDER VERMA4, RAJAT GOYAL5, GOVIND SINGH1, ARCHANA SHARMA6, NEHA RAO3, DEEPAK KAUSHIK1,*
Oncology Research, DOI:10.32604/or.2024.047278
Abstract Background:: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective:: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods:: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More >
Graphic Abstract
Open Access
ARTICLE
RUIFANG LI1, XINRONG NAN2,*, MING LI3,*, OMAR RAHHAL3
Oncology Research, DOI:10.32604/or.2024.046965
Abstract Background: Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. Objective: We aimed to assess the pan-cancer expression profile of FAP, its molecular function, and its potential role in head and neck squamous cell carcinoma (HNSC). Methods: We analyzed gene expression, survival status, immune infiltration, and molecular functional pathways of FAP in The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) tumors. Furthermore, to elucidate the role of FAP in HNSC, we performed proliferation, migration, and invasion assays post-FAP overexpression or knock-down.… More >
Open Access
ARTICLE
HAIQING HU1,#,*, HAO YANG2,#, SHUAISHUAI FAN3, XUE JIA3, YING ZHAO3, HONGRUI LI3
Oncology Research, DOI:10.32604/or.2024.044174
Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with CRC were assessed using the… More >
Open Access
ARTICLE
ZIYONG LIU1,#, TAO MA1,#, JINFANG LI2, WEI REN1,*, ZHIXIN ZHANG1,*
Oncology Research, DOI:10.32604/or.2024.048315
Abstract Background:: Interleukin 13 receptor subunit alpha 2 (IL13RA2) plays an essential role in the progression of many cancers. However, the role of IL13RA2 in infantile haemangioma (IH) is still unknown. Materials and Methods:: IL13RA2 expression in IH tissues was analyzed using western blot, qRT-PCR, and immunofluorescence. The role of IL13RA2 in haemangioma-derived endothelial cells (HemECs) was determined following knockdown or overexpression of IL13RA2 using CCK-8, colony formation, apoptosis, wound healing, tubule formation, Transwell, and western blot. Results:: IL13RA2 expression was upregulated in IH tissues. IL13RA2 overexpression promoted proliferation, migration, and invasion of HemECs and induced glycolysis, which was confirmed with… More >
Open Access
ARTICLE
SHAHID KARIM1,*, ALANOUD NAHER ALGHANMI1, MAHA JAMAL1, HUDA ALKREATHY1, ALAM JAMAL2, HIND A. ALKHATABI3, MOHAMMED BAZUHAIR1, AFTAB AHMAD4,5
Oncology Research, DOI:10.32604/or.2024.048988
（This article belongs to this Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in… More >
Graphic Abstract
Open Access
ARTICLE
CHAO TANG1,#, CHUNYU ZHONG2,#, JUNHAO ZHU1, FENG YUAN1, JIN YANG1, YONG XU3,*, CHIYUAN MA1,3,4,5,*
Oncology Research, DOI:10.32604/or.2024.046007
Abstract Approximately 30%–40% of growth hormone–secreting pituitary adenomas (GHPAs) harbor somatic activating mutations in GNAS (α subunit of stimulatory G protein). Mutations in GNAS are associated with clinical features of smaller and less invasive tumors. However, the role of GNAS mutations in the invasiveness of GHPAs is unclear. GNAS mutations were detected in GHPAs using a standard polymerase chain reaction (PCR) sequencing procedure. The expression of mutation-associated maternally expressed gene 3 (MEG3) was evaluated with RT-qPCR. MEG3 was manipulated in GH3 cells using a lentiviral expression system. Cell invasion ability was measured using a Transwell assay, and epithelial–mesenchymal transition (EMT)-associated proteins… More >
Open Access
REVIEW
NILAM BHUSARE, MAUSHMI KUMAR*
Oncology Research, DOI:10.32604/or.2024.047042
（This article belongs to this Special Issue: Advances in Cancer Therapeutics)
Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More >
Graphic Abstract
Open Access
ARTICLE
YE ZHANG1, YANAN LIANG2, YAN WU2, LIWEN SONG2, ZUWANG ZHANG2,*
Oncology Research, DOI:10.32604/or.2024.030945
Abstract Background: Papillary thyroid cancer (PTC) is the most prevalent histological type of differentiated thyroid malignancy. Circular RNAs (circRNAs) have been implicated in the pathogenesis and progression of various cancers. circTIAM1 (hsa_circ_0061406) is a novel circRNA with aberrant expression in PTC. However, its functional roles in PTC progression remain to be investigated. Methods: The expression levels of circTIAM1 in the PTC and the matched para-cancerous tissues were detected by quantitative real-time reverse-transcription PCR (qRT-PCR). The subcellular localization of circTIAM1 was examined by fluorescence in-situ hybridization (FISH). Kaplan-Meier plot was used to analyze the association of clinicopathological features with circTIAM1 expression. Bioinformatics… More >
Open Access
ARTICLE
PEILING WU#, LIFANG ZHAO#, HONGYAN ZHANG, YUEYAN LOU, DONGFANG CHEN, SHAN XUE, XUEQING LIU*, HANDONG JIANG*
Oncology Research, DOI:10.32604/or.2024.047490
Abstract The pro-oncogenic effects of NCAPD2 have been extensively studied across various tumor types; however, its precise role within the context of lung adenocarcinoma (LUAD) remains elusive. This study aims to elucidate the biological functions of NCAPD2 in LUAD and unravel the underlying mechanistic pathways. Utilizing bioinformatics methodologies, we explored the differential expression of NCAPD2 between normal and tumor samples, along with its correlations with clinical-pathological characteristics, survival prognosis, and immune infiltration. In the TCGA-LUAD dataset, tumor samples demonstrated significantly elevated levels of NCAPD2 expression compared to normal samples (p < 0.001). Clinically, higher NCAPD2 expression was notably associated with advanced… More >
Open Access
ARTICLE
KUN FENG1,#, HAO PENG2,#, QINGPENG LV1, YEWEI ZHANG1,*
Oncology Research, DOI:10.32604/or.2024.047078
Abstract Hepatocellular carcinoma (HCC) is a malignancy known for its unfavorable prognosis. The dysregulation of the tumor microenvironment (TME) can affect the sensitivity to immunotherapy or chemotherapy, leading to treatment failure. The elucidation of PHLDA2’s involvement in HCC is imperative, and the clinical value of PHLDA2 is also underestimated. Here, bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of HCC. Then, the expression and function of PHLDA2 were examined via the qRT-PCR, Western Blot, and MTT assays. Our findings indicate a substantial upregulation of PHLDA2 in HCC, correlated with… More >
Open Access
ARTICLE
ZHAOYING ZHU1,#, YANJIA HU2,#, FENG YE2, HAIBO TENG2, GUOLIANG YOU1, YUNHUI ZENG2, MENG TIAN2, JIANGUO XU2, JIN LI2, ZHIYONG LIU2, HAO LIU2,*, NIANDONG ZHENG1,*
Oncology Research, DOI:10.32604/or.2024.042456
Abstract Background: Inhibitor of NF-κB kinase-interacting protein (IKIP) is known to promote proliferation of glioblastoma (GBM) cells, but how it affects migration and invasion by those cells is unclear. Methods: We compared levels of IKIP between glioma tissues and normal brain tissue in clinical samples and public databases. We examined the effects of IKIP overexpression and knockdown on the migration and invasion of GBM using transwell and wound healing assays, and we compared the transcriptomes under these different conditions to identify the molecular mechanisms involved. Results: Based on data from our clinical samples and from public databases, IKIP was overexpressed in… More >
Open Access
ARTICLE
YUANLIN LIU1,3,#, YAN LIU2,#, YAN WANG2, QIANG WANG2, YAN YAN1, DANDAN ZHANG2,*, HUIQIN LIU2,*
Oncology Research, DOI:10.32604/or.2024.047454
Abstract At present, the role of many long non-coding RNAs (lncRNAs) as tumor suppressors in the formation and development of cervical cancer (CC) has been studied. However, lncRNA prostate cancer gene expression marker 1 (PCGEM1), whose high expression not only aggravates ovarian cancer but also can induce tumorigenesis and endometrial cancer progression, has not been studied in CC. The objective of this study was to investigate the expression and the underlying role of PCGEM1 in CC. The relative expression of PCGEM1 in CC cells was detected by real-time PCR. After the suppression of PCGEM1 expression by shRNA, the changes in the… More >
Graphic Abstract
Open Access
ARTICLE
SANDRA STICKLER, BARBARA RATH, GERHARD HAMILTON*
Oncology Research, DOI:10.32604/or.2024.045356
（This article belongs to this Special Issue: Recent Advances in Cancer Pharmacology)
Abstract Pancreatic cancer has a dismal prognosis due to late detection and lack of efficient therapies. The Kirsten rat sarcoma virus (KRAS) oncogene is mutated in up to 90% of all pancreatic ductal adenocarcinomas (PDACs) and constitutes an attractive target for therapy. However, the most common KRAS mutations in PDAC are G12D (44%), G12V (34%) and G12R (20%) that are not amenable to treatment by KRAS G12C-directed cysteine-reactive KRAS inhibitors such as Sotorasib and Adagrasib that exhibit clinical efficacy in lung cancer. KRAS G12C mutant pancreatic cancer has been treated with Sotorasib but this mutation is detected only in 2%–3% of… More >
Open Access
ARTICLE
EFFAT ALEMZADEH1, LEILA ALLAHQOLI2, AFROOZ MAZIDIMORADI3, ESMAT ALEMZADEH1,4, FAHIMEH GHASEMI4,5, HAMID SALEHINIYA6, IBRAHIM ALKATOUT7,*
Oncology Research, DOI:10.32604/or.2024.031006
Abstract Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for maintenance therapy. However, resistance to these new drugs has emerged. Therefore, understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective… More >
Open Access
ARTICLE
XIA DA1, HAN GE2, JUNFENG SHI3, CHUNHUA ZHU1, GUOZHU WANG1, YUAN FANG4,*, JIN XU1,*
Oncology Research, DOI:10.32604/or.2024.045433
（This article belongs to this Special Issue: Cancer Metastasis)
Abstract Objective: This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in triple-negative breast cancer (TNBC). Methods: ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and PCR. ROR2 expression in TNBC cell lines was detected by PCR and Western blot analysis. The migration, invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were examined. Results: ROR2 expression was high in metastatic TNBC tissues. ROR2 knockdown suppressed the migration, invasion and chemoresistance of TNBC cells. ROR2 overexpression in MDA-MB-435 cells promoted the migration, invasion, and chemoresistance. Moreover,… More >
Open Access
ARTICLE
ANGUO WU1,#, JIAO YAN2,3,#, TING SU2,4, CHI FENG1, XIN LONG5,6, YIRU PAN1, RUPEI YE2, TIAN XIA2, HANAN LONG2, JIANMING WU1,*, XIULI XIAO2,*
Oncology Research, DOI:10.32604/or.2024.046139
（This article belongs to this Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Breast cancer, a predominant global health issue, requires ongoing exploration of new therapeutic strategies. Palbociclib (PAL), a well-known cyclin-dependent kinase (CDK) inhibitor, plays a critical role in breast cancer treatment. While its efficacy is recognized, the interplay between PAL and cellular autophagy, particularly in the context of the RAF/MEK/ERK signaling pathway, remains insufficiently explored. This study investigates PAL’s inhibitory effects on breast cancer using both in vitro (MCF7 and MDA-MB-468 cells) and in vivo (tumor-bearing nude mice) models. Aimed at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib (TRA), an MEK… More >
Graphic Abstract
Open Access
ARTICLE
ANDI ZHAO1,2,#, YUE WANG3,#, ZIJIN WANG1,2, QING SHAO1,2, QI GONG1,2, HUI ZHU1,2, SHIYA SHEN1,2, HU LIU1,2,*, XUEJUAN CHEN1,2,*
Oncology Research, DOI:10.32604/or.2024.045972
（This article belongs to this Special Issue: Non-coding RNAs on the Clinical Application of Solid Cancers)
Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth… More >
Graphic Abstract
Open Access
ARTICLE
YUE ZHANG1,#, WENYU YANG1,#, XIAOWANG HAN1,#, YUE QIAO1, HAITAO WANG2, TING CHEN1, TIANYING LI1, WEN-BIN OU1,*
Oncology Research, DOI:10.32604/or.2024.045025
（This article belongs to this Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract It has been shown that the high expression of human epididymis protein 4 (HE4) in most lung cancers is related to the poor prognosis of patients, but the mechanism of pathological transformation of HE4 in lung cancer is still unclear. The current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma (LUAD). Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies, and through analysis of The Cancer Genome Atlas (TCGA) dataset. Frequent HE4 overexpression was demonstrated in LUAD, but not in lung squamous cell carcinoma (LUSC), indicating that… More >
Open Access
ARTICLE
XIAOXI WANG1, YANFEI JIA2, QIANG LI2, QIANG YANG2, YINGFENG LIU1, BEIFENG WEI1, XIANG NIU1, YINJIE ZHANG1, XIAODONG LUO2, ZIYU ZHAO1,*, PENG WANG1,*
Oncology Research, DOI:10.32604/or.2023.042581
Abstract MicroRNA (miR)-200b-3p has been associated with many tumors, but its involvement in pituitary adenoma is unclear. This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment. Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA. As well, the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay. The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization. Transfection of the miR-200b-3p inhibitor and small interfering-RECK (si-RECK) was verified by qPCR. GH3 cell viability and proliferation… More >
Open Access
ARTICLE
ZHEN LIU1,#, LIANGWANG YANG2,#, ZHENGXING XIE1, HUI YU3, TIANYI GU3, DAOMING SHI4, NING CAI1,*, SHENGHUA ZHUO2,*
Oncology Research, DOI:10.32604/or.2024.045769
（This article belongs to this Special Issue: Multi-Omics Approaches for Precision Medicine)
Abstract Clinical data indicates that glioma patients have poor treatment outcomes and clinical prognosis. The role of olfactory signaling pathway-related genes (OSPRGs) in glioma has not been fully elucidated. In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion… More >
Open Access
ARTICLE
YAN ZHANG, HEYANG ZHANG, JING WANG, XIN WEI, YI QU, FENG XU, LIJUN ZHANG*
Oncology Research, DOI:10.32604/or.2023.043922
Abstract Background: Bortezomib results in peripheral neuropathy (PN) in approximately 50% of patients, during multiple myeloma (MM) treatment, a complication known as Bortezomib-induced peripheral neuropathy (BIPN). The drug response varies among individuals. Genetic factor may play an important role in BIPN. Methods: A next-generation sequencing (NGS) panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy. mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR (RT-qPCR). Serum homocysteine (Hcy) levels were detected in 40 samples by chemiluminescent microparticle immunoassay… More >
Graphic Abstract
Open Access
ARTICLE
XUHUI ZHAO1,2, XIAOMIN HUANG1, CHUNYAN DANG2, XIA WANG1, YUJIAO QI3, HONGLING LI2,*
Oncology Research, DOI:10.32604/or.2024.046679
（This article belongs to this Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results: EBV-miRNA-BART6-5p exhibits pronounced upregulation… More >
Open Access
ARTICLE
JUNZHE YI1,#, BINBIN LI2,#, XIAOMIN YIN3, LINGRUI LIU1, CAILU SONG1, YING ZHAO4, MANBO CAI3, HAILIN TANG1, DONG CHEN4,*, NING LYU1,*
Oncology Research, DOI:10.32604/or.2024.047524
Abstract Circular RNAs (circRNAs) have been recognized as pivotal regulators in tumorigenesis, yet the biological
functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma (HCC) remain
elusive. We sought to unveil the expression profile and biological role of circMYBL2 in HCC. Initial microarray
analyses were conducted to probe the expression profile of circMYBL2 in HCC cells, and qRT‒PCR analysis was then
performed in HCC cell lines and tissues, revealing significant upregulation of circMYBL2. Subsequent experiments
were conducted to evaluate the biological function of circMYBL2 in HCC progression. Furthermore, bioinformatics
analysis, qRT‒PCR analysis, luciferase reporter assays, and… More >
Open Access
ARTICLE
JIANBO ZHOU1,2,3, FENG WAN2,4, BIN XIAO5, XIN LI1, CHENG PENG2,*, FU PENG1,3,*
Oncology Research, DOI:10.32604/or.2023.044775
（This article belongs to this Special Issue: Application of Multi-omics Analysis in Cancer Immunotherapy)
Abstract Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition in vitro, and reduced tumor growth in vivo. Moreover, transcriptomic analysis revealed that TEC modulated the activity… More >
Graphic Abstract
Open Access
ARTICLE
HASSAN BAYDOUN1, YUJI KATO1, HIROKI KAMO1, ANNA HÜSCH1,2, HAYATO MIZUTA1, RYOTA KAWAHARA1, SIRO SIMIZU1,*
Oncology Research, DOI:10.32604/or.2023.030304
（This article belongs to this Special Issue: Approach from Chemical Biology for Cancer Research)
Abstract C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic reticulum. In humans, biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family; nonetheless, biological functions of protein C-mannosylation are not yet fully understood, especially in tumor progression. Vasculogenic mimicry (VM) is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells, enabling the tumors to form matrix-embedded vasculogenic structures, containing plasma and blood cells to meet the metabolic demands of rapidly growing tumors. In this study, we focused on DPY19L3, a C-mannosyltransferase, and aimed to unravel its role in… More >
Open Access
ARTICLE
JIE ZHAO1,#, XUANTAO YANG2,#, HAIXI ZHANG1, XUEZHONG GU1,*
Oncology Research, DOI: 10.32604/or.2023.030770
Abstract Multiple myeloma (MM) is a hematological tumor with high mortality and recurrence rate. Carfilzomib is a
new-generation proteasome inhibitor that is used as the first-line therapy for MM. However, the development of drug
resistance is a pervasive obstacle to treating MM. Therefore, elucidating the drug resistance mechanisms is conducive
to the formulation of novel therapeutic therapies. To elucidate the mechanisms of carfilzomib resistance, we retrieved
the GSE78069 microarray dataset containing carfilzomib-resistant LP-1 MM cells and parental MM cells. Differential
gene expression analyses revealed major alterations in the major histocompatibility complex (MHC) and cell adhesion
molecules. The upregulation of the tumor… More >
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