Open Access

REVIEW

Ferroptosis’s Role in Genitourinary System Cancer

Chaoying Liu^1,#, Xinfeng Yang^2,#, Ye Wang^2,#, Keyu Wu², Siqiang Li², Gailing Wang², Yun Li², Chuanfeng Li², Mingcheng Wang², Enzhong Li^2,*

1 Zhumadian Academy of Industry Innovation and Development, HuangHuai University, Zhumadian, 463000, China
2 School of Biological and Food Processing Engineering, HuangHuai University, Zhumadian, 463000, China

* Corresponding Author: Enzhong Li. Email:
# These authors contributed equally to this work and share first authorship

(This article belongs to the Special Issue: Ferroptosis in the Occurrence and Treatment of Cancer)

Oncologie 2022, 24(4), 679-691. https://doi.org/10.32604/oncologie.2022.025705

Received 26 July 2022; Accepted 17 October 2022; Issue published 31 December 2022

Abstract

A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new avenues. Many studies have shown a complex link between ferroptosis and cancer, while some studies have also found the role of ferroptosis in genitourinary system-related cancers and therapeutic prospects. This article reviews the ferroptosis research progress in genitourinary system cancers, including bladder cancer, prostate cancer, ovarian cancer, and cervical cancer. It will also provide new ideas for the treatment of these cancers.

---

Keywords

---