TY - EJOU
AU - Jafari-Sales, Abolfazl
AU - Shariat, Afsoon
AU - Baghi, Hossein Bannazadeh
AU - Baradaran, Behzad
AU - Jafari, Behboud
TI - The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study
T2 - Oncologie
PY - 2022
VL - 24
IS - 3
SN - 1765-2839
AB - Background and Aim: Gastric cancer (GC) is one of the most common infection-related malignancies worldwide. Human Papillomavirus (HPV) and Epstein-Barr virus (EBV) are among the most important viruses affecting many people worldwide. The potential role of these viruses in gastric tissue may explain the possibility of GC,
as seen in Helicobacter pylori (H. pylori). This study aimed to systematically investigate the presence of HPV and
EBV in GC. Methods: According to the Preferred Reporting Items for Systematic reviews and Meta-Analyses
(PRISMA) guidelines, this study is a systematic review based on reported cases. The keywords HPV, EBV and
GC, were searched in PubMed, Web of Science, Scopus, EMBASE and Google scholar databases from 2012 to
2022. Articles were selected and evaluated by five researchers independently. The odds ratio of HPV and EBV
viruses in GC was estimated. Data analysis was performed by SPSS (Version 20) software. Results: Sixty studies
with 14949 patients were included in the study after obtaining the inclusion criteria. The mean prevalence of HPV
and EBV viruses in GC was 10.58% and 8.58%, respectively. The highest prevalence of HPV and EBV were 37.74%
and 44.44% in Turkey and Iraq, respectively. The highest odds of HPV and EBV in GC were observed in Asia
(17.54%) and Africa (19.02%), respectively. Conclusion: The findings indicate the presence of HPV and EBV
in GC in the study areas. However, the present study’s results are insufficient for a more accurate conclusion.
Therefore, further studies are necessary for the conclusion in this regard.
KW - Human Papillomavirus; Epstein-Barr virus; gastric cancer; systematic study
DO - 10.32604/oncologie.2022.024161