Open Access
ARTICLE
Comparison of IDEAL-IQ and IVIM-DWI for Differentiating between Alpha Fetoprotein-Negative Hepatocellular Carcinoma and Focal Nodular Hyperplasia
Shaopeng Li, Peng Wang, Jun Qiu, Yiju Xie, Dawei Yin, Kexue Deng*
Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial
Hospital), Hefei, 230032, China
* Corresponding Author: Kexue Deng. Email:
Oncologie 2022, 24(3), 527-538. https://doi.org/10.32604/oncologie.2022.022815
Received 27 March 2022; Accepted 26 June 2022; Issue published 19 September 2022
Abstract
Background: To compare the differential diagnostic value of iterative decomposition of water and fat with the
echo asymmetrical and least-squares estimation quantitation sequence (IDEAL-IQ) with that of intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) in differentiating between alpha fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH).
Materials and Methods: A total of
28 AFP-negative HCC cases and 15 FNH cases were scanned using the IDEAL-IQ and IVIM-DWI magnetic resonance imaging (MRI) protocols. Two radiologists independently assessed the fat fraction (FF) and the iron level
surrogate (R2*) derived from the IDEAL-IQ images and the apparent diffusion coefficient (ADC), pure diffusion
coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) derived from the IVIM-DWI images.
The intraclass correlation coefficients (ICC) were estimated to evaluate the agreement repeatability between the
two readers. The area under the curve (AUC) of a receiver operating characteristics curve was used to compare
the diagnostic efficiency of the parameters extracted from the two techniques.
Results: The lesions in the HCC
group had significantly higher FF than the FNH group (8.284 ± 5.756 vs. 2.559 ± 1.247,
P < 0.05). ADC and D
values were lower in the HCC lesions when compared with the FNH lesions (1.310 ± 0.253 and 0.909 ± 0.192,
respectively, vs. 1.624 ± 0.304 and 1.230 ± 0.314; ×10
−3 mm
2
/s). The FF parameter had the highest AUC (0.923)
followed by D (0.864) and ADC (0.854).
Conclusions: FF derived from IDEAL-IQ, and ADC and D derived from
IVIM-DWI were able to differentiate AFP-negative HCC from FNH. IDEAL-IQ showed better performance for
the differentiation of FNH from HCC than the IVIM-DWI-derived parameters.
Keywords
Cite This Article
APA Style
Li, S., Wang, P., Qiu, J., Xie, Y., Yin, D. et al. (2022). Comparison of IDEAL-IQ and IVIM-DWI for differentiating between alpha fetoprotein-negative hepatocellular carcinoma and focal nodular hyperplasia. Oncologie, 24(3), 527-538. https://doi.org/10.32604/oncologie.2022.022815
Vancouver Style
Li S, Wang P, Qiu J, Xie Y, Yin D, Deng K. Comparison of IDEAL-IQ and IVIM-DWI for differentiating between alpha fetoprotein-negative hepatocellular carcinoma and focal nodular hyperplasia. Oncologie . 2022;24(3):527-538 https://doi.org/10.32604/oncologie.2022.022815
IEEE Style
S. Li, P. Wang, J. Qiu, Y. Xie, D. Yin, and K. Deng "Comparison of IDEAL-IQ and IVIM-DWI for Differentiating between Alpha Fetoprotein-Negative Hepatocellular Carcinoma and Focal Nodular Hyperplasia," Oncologie , vol. 24, no. 3, pp. 527-538. 2022. https://doi.org/10.32604/oncologie.2022.022815