Open Access

REVIEW

Progression of Exosome-Mediated Chemotherapy Resistance in Cancer

by Haojie Zhang¹, Xiaohong Wang^2,*, Yue Yu², Zhenlin Yang^3,*

1 Binzhou Medical University, Yantai, 264003, China
2 Department of Breast Surgery, Binzhou Medical University Hospital, Binzhou, 256603, China
3 Department of Thyroid and Breast Surgery, Binzhou Medical University Hospital, Binzhou, 256603, China

* Corresponding Authors: Xiaohong Wang. Email: ; Zhenlin Yang. Email:

Oncologie 2022, 24(2), 247-259. https://doi.org/10.32604/oncologie.2022.020993

Received 22 December 2021; Accepted 12 April 2022; Issue published 29 June 2022

Abstract

Chemotherapy plays an important role in controlling cancer progression, but the long-term use of chemotherapeutic agents can lead to drug resistance and eventually treatment failure. Therefore, elucidation of the mechanism of drug resistance is the key to solve the problem of chemotherapy resistance. In recent years, exosomes derived from tumor cells have received extensive attention from researchers. In this paper, we reviewed the role and mechanism of exosome-mediated tumor drug resistance in recent years, summarized the related studies of exosome and chemotherapy drug resistance, and focused on several different ways by which exosomes participate in tumor drug resistance. It includes the transporters of non-coding RNAs (ncRNAs), active proteins, stromal cell-derived exosomes and exosomes that directly mediate the efflux of drug molecules. Our review suggests that exosomes can play a role in the treatment of tumor drug resistance by inhibiting the secretion of exosomes, providing a new idea for the prevention and treatment of tumor chemotherapy drug resistance.

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Keywords

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