Open Access

REVIEW

Gene Editing in Non-Small Cell Lung Cancer: Current Application and Future Perspective

by Hangxing Wang^1,#, Jingyun Fang^1,#, Yujiao Wang^2,#, Shuo Li², Zirui Wang², Wei He², Nan Wang¹, Shuang Luo¹, Huimei Zou^3,*, Fan Zhang^4,5,*

1 Clinical Medical College, Guizhou Medical University, Guiyang, 550004, China
2 Second Clinical Medical College of Lanzhou University, Lanzhou, 730000, China
3 School of Nursing, Guizhou Medical University, Guiyang, 550025, China
4 Department of Pathophysiology, Guizhou Medical University, Guiyang, 550025, China
5 Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China

* Corresponding Authors: Huimei Zou. Email: ; Fan Zhang. Email:
# Equal Contribution: Hangxing Wang, Jingyun Fang and Yujiao Wang contributed to this work equally and should be regarded as co-first authors

Oncologie 2022, 24(1), 65-83. https://doi.org/10.32604/oncologie.2022.021863

Received 10 February 2022; Accepted 06 March 2022; Issue published 31 March 2022

Abstract

Lung cancer is the most common malignant tumor with the highest morbidity and mortality in the world, and non-small cell lung cancer (NSCLC) accounts for the vast majority of cases. At present, its main treatment methods are still traditional surgery, radiotherapy and chemotherapy, with disadvantages such as a high recurrence rate and limited effectiveness. Therefore, a new, better treatment method is urgently needed. Gene editing technology, as a new genetic engineering approach, has shown great potential in gene research, gene therapy and genetic improvement. It has also emerged as a promising treatment for lung cancer. This paper reviews the current research and applications of gene editing technology in NSCLC and other aspects of NSCLC, the therapeutic principle and mechanism of action, and the existing problems and prospects. This review aims to provide a basis for the prevention and treatment of NSCLC in the future and improve the survival rate of lung cancer patients.

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