Open Access

EDITORIAL

Daniel Serin
Oncologie, Vol.24, No.1, pp. 1-2, 2022, DOI:10.32604/oncologie.2022.020553 - 31 March 2022
Abstract This article has no abstract. More >

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REVIEW

Elsa Maitre, Xavier Troussard^*
Oncologie, Vol.24, No.1, pp. 3-24, 2022, DOI:10.32604/oncologie.2022.021490 - 31 March 2022
Abstract La leucémie à tricholeucocytes (LT) représente 2% de l’ensemble des leucémies. Le diagnostic repose sur la présence dans le sang et/ou la moelle de tricholeucocytes: cellules lymphoïdes B au cytoplasme chevelu exprimant le CD103, CD123, CD11c et CD25. La mutation BRAF^V600E, marqueur moléculaire de la maladie, est présente dans plus de 80% des cas. La LT doit être distinguée des autres syndromes lymphoprolifératifs chroniques B, notamment des autres proliférations à cellules chevelues, forme variante de la leucémie à tricholeucocytes (LT-V) et lymphome splé- nique diffus de la pulpe rouge (LSDPR). Des progrès thérapeutiques ont été récemment… More >

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VIEWPOINT

Jean-Claude Ferrandez^1,*, Pierre-Henri Ganchou², Serge Theys³, Maria Torres-Lacomba⁴, Daniel Serin¹
Oncologie, Vol.24, No.1, pp. 25-33, 2022, DOI:10.32604/oncologie.2022.018110 - 31 March 2022
Abstract Le lymphœdème du membre supérieur est une séquelle du traitement des cancers du sein. Le traitement physique des lymphœdèmes est recommandé par la Société internationale de lymphologie. Il associe drainage lymphatique manuel et bandages de décongestion. Le drainage lymphatique manuel a fait l’objet de critiques quant à son effi- cacité. Or depuis son invention dans les années 1930, de très nombreuses techniques s’intitulent « drainage lymphatique manuel ». Les auteurs distinguent l’efficacité de ces différentes techniques en fonction des données de la physiologie lymphatique et de la démonstration de ses effets basée sur les faits. More >

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Federico Cappellacci^*, Gian Luigi Canu, Stefano Piras, Giacomo Anedda, Pietro Giorgio Calò, Fabio Medas
Oncologie, Vol.24, No.1, pp. 35-50, 2022, DOI:10.32604/oncologie.2022.020864 - 31 March 2022
Abstract Thyroid cancer is the fifth most common cancer in the USA, with differentiated subtype accounting for more than 95% of neoplasm. Surgery remains the mainstay of treatment, either with lobectomy or total thyroidectomy. In the last decades, many technological innovations have been introduced in this field. The aim of this review is to illustrate the most recent advances regarding the classical surgical approach, particularly regarding hemostatic devices, parathyroid identification with fluorescence systems, intraoperative identification of lymph node metastases, and intraoperative neuromonitoring. More >

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Hiba Alzoubi¹, Alameen Alsabbah², Rosario Caltabiano³, Giuseppe Broggi^3,*
Oncologie, Vol.24, No.1, pp. 51-63, 2022, DOI:10.32604/oncologie.2022.020890 - 31 March 2022
Abstract The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) improved our understanding of the brain neoplasm biology. In more details, differences between diffuse gliomas that primarily occur in adults and those that primarily occur in children have been identified by the terms “adult-type” and “pediatric-type” diffuse gliomas. More importantly, both diagnostic and grading criteria for adult-type diffuse astrocytomas have been modified, by adopting novel molecular markers: diffuse astrocytomas, IDH-mutant have been grouped into a single entity and graded as CNS WHO grades 2, 3, or 4, with the assignment of More >

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REVIEW

Hangxing Wang^1,#, Jingyun Fang^1,#, Yujiao Wang^2,#, Shuo Li², Zirui Wang², Wei He², Nan Wang¹, Shuang Luo¹, Huimei Zou^3,*, Fan Zhang^4,5,*
Oncologie, Vol.24, No.1, pp. 65-83, 2022, DOI:10.32604/oncologie.2022.021863 - 31 March 2022
Abstract Lung cancer is the most common malignant tumor with the highest morbidity and mortality in the world, and non-small cell lung cancer (NSCLC) accounts for the vast majority of cases. At present, its main treatment methods are still traditional surgery, radiotherapy and chemotherapy, with disadvantages such as a high recurrence rate and limited effectiveness. Therefore, a new, better treatment method is urgently needed. Gene editing technology, as a new genetic engineering approach, has shown great potential in gene research, gene therapy and genetic improvement. It has also emerged as a promising treatment for lung cancer. More >

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REVIEW

Hao Luo^1,#,*, Yanjie Ji^2,#, Xinrong Gao¹, Xinying Liu¹, Yunzhao Wu³, Yingli Wu^3,*
Oncologie, Vol.24, No.1, pp. 85-99, 2022, DOI:10.32604/oncologie.2022.021705 - 31 March 2022
Abstract The ubiquitin-proteasome system (UPS) is an important pathway for cellular protein degradation. The components of this pathway, including the proteasome, ubiquitinase, and deubiquitinase, are highly specialized and strictly regulated. The ubiquitin-specific protease 2 (USP2) belongs to the ubiquitin-specific proteases, a subgroup of deubiquitinating enzymes. USP2 plays essential roles in regulating cell survival, cell cycle, circadian rhythm, cell metabolism, inflammatory response, antiviral response, and metastasis by interacting with certain proteins such as Cyclin D1, PER1, CRY1, HDM2/p53, FASN, LDLR, TRAF6, TBK1, and TGFBR1-TGFBR2 complex. Elevation of USP2 has been observed in a variety of cancers, including… More >

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ARTICLE

Dong Yan^1,#, Chunxiao Li^2,#, Yantong Zhou², Xue Yan¹, Weihua Zhi¹, Haili Qian^2,*, Yue Han^1,*
Oncologie, Vol.24, No.1, pp. 101-111, 2022, DOI:10.32604/oncologie.2022.020357 - 31 March 2022
Abstract Hepatocellular carcinoma (HCC) is one of the most deadly types of cancer. Sorafenib is currently the only available first-line molecular targeted drug approved by the FDA for HCC. However, primary and secondary resistance is often encountered with treatment with sorafenib. Genomic alterations found in HCC represent potential targets to develop new drugs or new combinational strategies against this type of cancer. Here we analyzed genomic alterations from the TCGA database of HCC samples and the corresponding targeted drugs available to the clinic to identify candidate drugs that might hold promise when used in combination with… More >

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ARTICLE

Beifen Dai^1,#, Zhihao Xu^2,#, Hongjue Li³, Bo Wang³, Jinsong Cai¹, Xiaomo Liu^4,*
Oncologie, Vol.24, No.1, pp. 113-130, 2022, DOI:10.32604/oncologie.2022.020259 - 31 March 2022
Abstract Large-scale genomic studies are important ways to comprehensively decode the human genomics, and provide valuable insights to human disease causalities and phenotype developments. Genomic studies are in need of high throughput bioinformatics analyses to harness and integrate such big data. It is in this overarching context that artificial intelligence (AI) offers enormous potentials to advance genomic studies. However, racial bias is always an important issue in the data. It is usually due to the accumulation process of the dataset that inevitability involved diverse subjects with different races. How can race bias affect the outcomes of… More >

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ARTICLE

Jiayi Huang¹, Xue Bai¹, Xiaofeng Xie¹, Liping Chen¹, Xiaofeng Lan¹, Qiuyi Zhang¹, Lin Song¹, Pengjiao Hong^2,3, Caiwen Du^1,*
Oncologie, Vol.24, No.1, pp. 131-145, 2022, DOI:10.32604/oncologie.2022.019881 - 31 March 2022
Abstract Background: Vinorelbine can be used to treat metastatic breast cancer as a single agent or in combination with other chemotherapy agents, although there is little real-world data for its use, particularly the oral form, in China. The current study aimed to explore the efficacy and safety of oral vinorelbine in patients with metastatic breast cancer in real-world clinical practice. Methods: A total of 194 patients with metastatic breast cancer received oral vinorelbine as a treatment between February 2017 and January 2021 at the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese… More >

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ARTICLE

Yi Zheng¹, Youyou Wang², Chen Zou¹, Bicheng Hu², Min Zhao², Xinxing Wu^2,*
Oncologie, Vol.24, No.1, pp. 147-161, 2022, DOI:10.32604/oncologie.2022.019236 - 31 March 2022
Abstract Tumor-associated macrophages (TAMs) are important components in tumor microenvironment. This study intended to explore the influence of TAMs on cervical cancer cells proliferation and migration. The expression levels of TAMs markers, CD68 and CD163, in tissues were examined by immunohistochemistry and increased with the progression of cervical lesions (p < 0.05). TAMs with M2-like phenotype (PMA(Polymethacrylate) induced THP-1 cells) were noticed to promote the proliferation of cervical cancer cells and improve the migration ability of tumor cells. These enhancements were attributed to secreting soluble components and the physical contact between macrophages and tumor cells. The tumor More >

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CASE REPORT

Ismail Bozkurt^1,*, Baris Yasar¹, Mehmet Baran Uslu², Nazan Bozdogan³
Oncologie, Vol.24, No.1, pp. 163-171, 2022, DOI:10.32604/oncologie.2022.019263 - 31 March 2022
Abstract Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and is difficult to manage. Metastasis is not uncommon (up to 31% of all cases) and is closely associated with a poor prognosis. Although rare (4–5%), extracutaneous melanoma has been reported; however, primary malignant melanoma of the sacrum is extremely rare (only three case reports to date). Here, we present a 51-year-old patient who underwent surgical treatment for a lesion of the spinal canal and associated bony structures; extensive aggressive resection was required. She underwent partial sacrectomy and lumbo-iliac fixation (to maintain More >

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