Open Access

ARTICLE

Circular RNA hsa_circ_0016863 Regulates the Proliferation, Migration, Invasion and Apoptosis of Hepatocellular Carcinoma

by Ping Zhao^1,#, Yao Xu^1,#, Anqi Wu², Yuhao Hu², Aiting Cai², Xinyue Wang³, Feng Wang^2,*, Xiang Chen^1,*

1 Department of Laboratory Medicine, Nantong City No.1 People’s Hospital and Second Affiliated Hospital of Nantong University, Nantong, China
2 Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China
3 Department of Laboratory Medicine, School of Public Health, Nantong University, Nantong, China
# Ping Zhao and Yao Xu contributed equally to this work

* Corresponding Authors:Xiang Chen. Email: ; Feng Wang. Email:

Oncologie 2021, 23(4), 589-601. https://doi.org/10.32604/oncologie.2021.018713

Received 12 August 2021; Accepted 21 October 2021; Issue published 31 December 2021

Abstract

Background: Although there has been a part of research that the expression of circular RNAs (circRNAs) is bound up with the occurrence, development and prognosis of multiple tumors, what roles circRNAs have in hepatocellular carcinoma (HCC) remain to be explored. Methods: Hsa_circ_0016863 showed a trend of high expression in HCC tissues by Microarray GSE97332. The expression of hsa_circ_0016863 in HCC and adjacent non-cancerous tissues was detected by qRT-PCR. The role of hsa_circ_0016863 in HCC was investigated by colony formation assay, cell proliferation assay, Transwell assay and flow cytometry. Results: Hsa_circ_0016863 exhibited a trend of high expression in HCC. Cell experiments showed that upregulated hsa_circ_0016863 promoted HCC cell proliferation, migration and invasion, whereas it inhibited cell apoptosis, while silencing hsa_circ_0016863 showed the opposite results. Conclusions: Hsa_circ_0016863 shows a trend of high expression in HCC, which may be related to the development of HCC.

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