Open Access

REVIEW

Epigenetics of Sirtuins: Relevance to Hepatocellular Carcinoma

by Xingyu Zhu^1,2,#, Yongjun Wang^3,#, Shuang Chang^4,#, Yue Su², Cuixia He¹, Shuang Hu⁵, Minhui Zhu¹, Yuzhou Ding², Nuannuan Ren², Qizhi Wang², Jing Xie^1,*, Huan Zhou^1,2,*

1 National Drug Clinical Trial Center, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, China
2 School of Pharmacy, Bengbu Medical College, Bengbu, 233000, China
3 School of Design, Hefei University, Hefei, 230601, China
4 The Affiliated Anqing Hospital of Anhui Medical University, Anqing, 230022, China
5 School of Pharmacy, Anhui Medical University, Hefei, 230032, China
# Xingyu Zhu, Yongjun Wang and Shuang Chang contributed equally to this work

* Corresponding Authors:Jing Xie. Email: ; Huan Zhou. Email:

Oncologie 2021, 23(4), 569-588. https://doi.org/10.32604/oncologie.2021.018869

Received 23 August 2021; Accepted 19 October 2021; Issue published 31 December 2021

Abstract

Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the main regulatory role and function of SIRTs in HCC and evaluates SIRTs as new targets for HCC treatment.

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Keywords

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