Open Access

REVIEW

The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

Zhengyi Li^1,2,3, Lihua Qiu^1,2,3,*

1 College of Stomatology, Chongqing Medical University, Chongqing, 401147, China
2 Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147, China
3 Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China

* Corresponding Author: Lihua Qiu. Email:

Oncologie 2021, 23(4), 515-531. https://doi.org/10.32604/oncologie.2021.019856

Received 20 October 2021; Accepted 13 December 2021; Issue published 31 December 2021

Abstract

Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies can selectively kill local tumors without endangering normal tissues. At present, there are more and more researches on optimizing the pharmacological properties of Ce6-based therapeutic agents. Therefore, this review focuses on the properties of Ce6 and the research progress of various nano-scale delivery strategies based on Ce6 in tumor treatment. At last, we summarized the positive impact and bright prospects of Ce6-based nanomaterials in cancer treatment applications.

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