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ARTICLE

Delphine Déniel^1,2,*, Fabienne Le Goc-Le Sager¹, Paul Touchard³, Véronique Marty⁴, Laurence Hasle⁵, Véronique Jestin Le Tallec⁶, Monique Jegaden⁷, Annaïk Pestel⁸, Virginie Jannou⁵, Sophie Pentecôte⁹, Laurence Guen^1,2, Christophe Perrin^1,10, Sandrine Estivin^1,3
Oncologie, Vol.23, No.4, pp. 453-461, 2021, DOI:10.32604/oncologie.2021.019964 - 31 December 2021
Abstract Contexte : Depuis le 25 janvier 2021, la vaccination de la COVID-19 a pu être réalisée en France auprès des personnes âgées de 75 ans et plus. Les patients souffrant d’une maladie cancéreuse font partie des groupes à risque de développer des complications sévères à la COVID-19. Méthode : L’Unité de Coordination en Onco-Gériatrie région Bretagne a souhaité mettre en place une enquête sur l’acceptabilité du patient âgé porteur de cancer et sur la tolérance à la vaccination anti-COVID 19 dans la région Bretagne. Résultats : L’étude a été réalisée entre le 1^er mai 2021 et le 31 août 2021… More >

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REVIEW

Mengdan Ma^1,2, Yuchen Liu^1,*, Weiren Huang^1,*
Oncologie, Vol.23, No.4, pp. 463-492, 2021, DOI:10.32604/oncologie.2022.019415 - 31 December 2021
Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals. This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the genetic components of a system has led to various practical applications, such… More >

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ARTICLE

Raghav Mishra^1,2,*, Nitin Kumar³, Neetu Sachan²
Oncologie, Vol.23, No.4, pp. 493-514, 2021, DOI:10.32604/oncologie.2021.018532 - 31 December 2021
Abstract The relevance of Retinoic acid receptor-related orphan receptors in cancer progression has sparked interest in developing multifunctional therapeutics. In the search for potentially active novel compounds with anticancer characteristics, the Gewald reaction was employed to develop different thiophene derivatives (8a–8i). Physicochemical and spectroanalytical investigations verified the molecular structures of the synthesized derivatives. Using an in vitro primary anticancer assay, NCI chose all of the synthesized molecules as prototypes and assessed their anticancer efficacy against a panel of various cancer cell lines representing nine distinct neoplasms. The compounds were found to have a wide range of anticancer… More >

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1408

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Zhengyi Li^1,2,3, Lihua Qiu^1,2,3,*
Oncologie, Vol.23, No.4, pp. 515-531, 2021, DOI:10.32604/oncologie.2021.019856 - 31 December 2021
Abstract Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment More >

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1503

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ARTICLE

Xubin Yin¹, Bing Yang², Ming Su², Shaoshan Sun¹, Hao Wang^1,*
Oncologie, Vol.23, No.4, pp. 533-546, 2021, DOI:10.32604/oncologie.2021.018705 - 31 December 2021
Abstract Background: Tumor recurrence is one of the major problems that affect the postoperative efficacy of oral squamous cell carcinoma (OSCC) treatment. Autophagy is known to have a dual-sided effect on tumors. However, studies on autophagy and prognosis are limited. The purpose of this study is to analyze the relationship between autophagy and OSCC recurrence. Materials and methods: 72 patients with OSCC were followed for 5 years after curative surgery. Tissue specimens from each patient were divided into tumor, normal, and marginal groups. Autophagy protein expression was assessed by western blotting and immunofluorescence. Statistical significance was evaluated using… More >

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ARTICLE

Adekunle Babajide Rowaiye^1,2, Moses Okonkwo Njoku³, Angus Nnamdi Oli², Sousan Akrami^4,5, Titilayo Asala¹, Ikemefuna Chijioke Uzochukwu⁶, Alex Akpa¹, Morteza Saki^4,5,*, Charles Okechukwu Esimone²
Oncologie, Vol.23, No.4, pp. 547-557, 2021, DOI:10.32604/oncologie.2021.019738 - 31 December 2021
Abstract Nonsteroidal anti-inflammatory drugs have a number of side effects. However, some medicinal herbs have anti-inflammatory properties with few side effects. This study aimed to determine the effect of the aqueous extract of Gongronema latifolium (AEGL) leaves on the level of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in rabbits. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the effect of the AEGL on the activities of pro-inflammatory cytokine (TNFα), and regulatory cytokine (TGF-β) in rabbits. Also, a colorimetric method was performed to evaluate the levels of AST and More >

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1165

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Xiaodan He, Jingshi Wang, Zhao Wang^*
Oncologie, Vol.23, No.4, pp. 559-567, 2021, DOI:10.32604/oncologie.2021.018647 - 31 December 2021
Abstract Despite extensive work-ups, some patients have been diagnosed with hemophagocytic lymphohistiocytosis (HLH) of unknown etiology. For HLH of unknown etiology, to investigate the clinical features and the factors that may affect the prognosis, we retrospectively reviewed the medical records of 94 patients hospitalized from January 2014 to December 2019. Survival times were evaluated until April 2020. For the 94 patients, the underlying causes of their diseases remained unclear at the end of the follow-up period, and the 1-, 3-, and 6-month survival rates, and the overall survival (OS) rates were 86.2%, 78.7%, 73.4%, and 70.2%,… More >

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1206

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Xingyu Zhu^1,2,#, Yongjun Wang^3,#, Shuang Chang^4,#, Yue Su², Cuixia He¹, Shuang Hu⁵, Minhui Zhu¹, Yuzhou Ding², Nuannuan Ren², Qizhi Wang², Jing Xie^1,*, Huan Zhou^1,2,*
Oncologie, Vol.23, No.4, pp. 569-588, 2021, DOI:10.32604/oncologie.2021.018869 - 31 December 2021
Abstract Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the More >

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1283

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ARTICLE

Ping Zhao^1,#, Yao Xu^1,#, Anqi Wu², Yuhao Hu², Aiting Cai², Xinyue Wang³, Feng Wang^2,*, Xiang Chen^1,*
Oncologie, Vol.23, No.4, pp. 589-601, 2021, DOI:10.32604/oncologie.2021.018713 - 31 December 2021
Abstract Background: Although there has been a part of research that the expression of circular RNAs (circRNAs) is bound up with the occurrence, development and prognosis of multiple tumors, what roles circRNAs have in hepatocellular carcinoma (HCC) remain to be explored. Methods: Hsa_circ_0016863 showed a trend of high expression in HCC tissues by Microarray GSE97332. The expression of hsa_circ_0016863 in HCC and adjacent non-cancerous tissues was detected by qRT-PCR. The role of hsa_circ_0016863 in HCC was investigated by colony formation assay, cell proliferation assay, Transwell assay and flow cytometry. Results: Hsa_circ_0016863 exhibited a trend of high expression in More >

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CASE REPORT

Dang Quang Hung^1,#, Nguyen-Thi Nhan¹, Trinh-Thi Phuong Nga¹, Nguyen Thanh Hai¹, Nguyen Quang Duc¹, Nguyen Viet Thu¹, Nguyen Truong Duc¹, Dinh-Van Thuyet¹, Nguyen Minh Duc^2,#,*,ORCID
Oncologie, Vol.23, No.4, pp. 603-608, 2021, DOI:10.32604/oncologie.2021.019519 - 31 December 2021
Abstract Metastatic spread of hepatocellular carcinoma (HCC) to the spleen is uncommon, only occurring in approximately 1% of cases. Atraumatic splenic rupture due to HCC metastasis is extremely rare and affects patient prognosis, clinical management, and mortality. We report a case of a 65-year-old man with a history of chronic hepatitis B infection who presented with left-sided abdominal pain and fatigue. Clinical examination showed acute anemia with elevated levels of serum alpha-fetoprotein (AFP) and protein induced by vitamin K absence (PIVKA-II). On ultrasound and computed tomography imaging, hemoperitoneum caused by a ruptured splenic tumor was revealed. More >

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1551

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RETRACTION

Yuqin Xie, Shuang Deng, Qian Deng, Jiudong Xu
Oncologie, Vol.23, No.4, pp. 609-609, 2021, DOI:10.32604/oncologie.2021.020379 - 31 December 2021
Abstract This article has no abstract. More >

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1335