Open Access

REVIEW

Circulating circRNAs as Potential Biomarkers for Cancers

Ruoyu Liu^1,#, Yuhao Hu^1,#, Jing Xu², Aiting Cai¹, Anqi Wu¹, Lin Chen³, Weihua Cai³, Deping Dong⁴, Henggui Xu^5,*, Feng Wang^1,*

1 Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China
2 Department of Laboratory Medicine, School of Public Health, Nantong University, Nantong, China
3 Department of Gastroenterology and Laboratory Medicine, Nantong Third Hospital Affiliated to Nantong University, Nantong, China
4 Department of Laboratory Medicine, Hai’an People’s Hospital Affiliated to Nantong University, Nantong, China
5 Department of Laboratory Medicine, Taizhou Jiangyan Hospital of Traditional Chinese Medicine, Taizhou, China

* Corresponding Authors: Henggui Xu. Email: ; Feng Wang. Email:
# Co-first authors

Oncologie 2021, 23(3), 303-320. https://doi.org/10.32604/oncologie.2021.018514

Received 30 July 2021; Accepted 03 September 2021; Issue published 26 September 2021

Abstract

Cancers are diseases with a high mortality rate worldwide. In order to better diagnose and improve the survival rate, many studies have been conducted. In recent years, the role of non-coding RNAs in cancers has been confirmed, and circular RNAs (circRNAs) have attracted much attention. CircRNAs are involved in the occurrence and development of cancers with high stability. Experiments have shown that they can exist stably in peripheral blood. Therefore, the expression of circulating circRNAs can be detected to help diagnose cancers and reflect tumor progression. In this review, we summarized the role of circulating circRNAs in cancers and discussed their potential as biomarkers.

---

Keywords

---