Open Access
EDITORIAL
Laurence Desjardins*
Oncologie, Vol.22, No.4, pp. 189-194, 2020, DOI:10.32604/oncologie.2020.012377
Abstract We describe the most frequent malignant intraocular tumors,
conjunctival tumors and some lids and orbital tumors. Primary intraocular
malignant tumors are retinoblastoma in children and uveal melanoma in adults.
For uveal melanoma, the liver is the most frequent site of metastasis and this is
why it is justified to prescribe liver ultrasonography every 6 months to these
patients. Metastatic tumors can occur in the uvea and more frequently in the
posterior part called the choroid. They are more frequent after breast cancer and
lung cancer. Conjunctival tumors can be epithelial (benign papillomas and
epidermoid carcinomas) or melanocytic (benign naevi and… More >
Open Access
ARTICLE
Sophie Gardrat*, Vincent Cockenpot
Oncologie, Vol.22, No.4, pp. 195-202, 2020, DOI:10.32604/oncologie.2020.013698
Abstract The pathological examination of ocular tumors has specificities in terms
of macroscopic management, microscopic analysis, and molecular examinations
requiring special attention. We discuss here the difficulties encountered in the
reception in the pathological anatomy laboratory of conjunctival samples,
enucleation and orbital exenteration pieces, then detail the diagnostic and theranostic,
microscopic and molecular characteristics of ocular tumor pathologies. Conjunctival
tumors (epithelial, melanocytic and lymphoid), choroidal tumors (including uveal
melanoma) and retinoblastoma are treated. Because of their low frequency and
their features, these tumors should be the subject of anatomo-clinical discussions.
Résumé:
L’examen anatomopathologique des tumeurs oculaires comporte des
spécificités en termes… More >
Open Access
ARTICLE
Sophie Piperno-Neumann1,*, Pascale Mariani2, Vincent Servois3, Gaelle Pierron4, Livia LumbrosoRouic5, Alexandre Matet5,6, Manuel Rodrigues1, Nathalie Cassoux5,6
Oncologie, Vol.22, No.4, pp. 203-212, 2020, DOI:10.32604/oncologie.2020.014102
Abstract Uveal melanoma is a rare subtype of melanoma, intrinsically
different from cutaneous melanoma. Despite optimal therapeutic management
allowing local control of the primary ocular tumor, 20 to 50% of patients
develop metastases, mainly localized to the liver, with a poor prognosis and a
12-month median survival from the diagnosis of the metastatic disease. There is
a lack of effective treatments in the metastatic setting, and dedicated strategies
and trials for uveal melanoma patients are needed, based on identification of
new targets and specific preclinical findings.
Résumé:
Le mélanome de l’uvée est un cancer rare, en tous points différent du
mélanome… More >
Open Access
REVIEW
Dheeraj Kumar Sharma1, Ahsas Goyal2,*, Shashank Chaturvedi2,*
Oncologie, Vol.22, No.4, pp. 213-224, 2020, DOI:10.32604/oncologie.2020.014926
Abstract Cancer results due to an imbalance between regulation of cell
proliferation and apoptosis. As per the latest data released by World Health
Organization (WHO), a large part of global population cannot access proper anticancer therapy, and this imposes a burden of approximately US$ 1.16 trillion on
global economy. Relevant studies were identified through electronic searches of
Pubmed, Medline, Scopus, Google scholar. In this review, we found that there is
extensive range of dietary items whose components can influence either cell
proliferation rate or cell death rate or both. Exclusion and avoidance of several
dietary items/habits are linked with reduced risk… More >
Open Access
ARTICLE
Neslihan Duzkale1,*, Emine Demıral2
Oncologie, Vol.22, No.4, pp. 225-234, 2020, DOI:10.32604/oncologie.2020.014120
Abstract Multiple primary malignant neoplasms (MPMN) are rare tumors that
have attracted attention with increasing incidence rates in recent years and where
cancer susceptibility genes may play a role in their etiology. In this study, it was
aimed to determine the genotype-phenotype correlation in patients with MPMN.
From January 2018 to January 2020, thirty patients were analyzed for 59 cancer
susceptibility genes and diagnosed with MPMN, using a large multigene panel
with Next Generation Sequencing technique (NGS) in Turkey. The mean age of
first and second cancer diagnosis of cases were calculated as 42.5 and 49.9
(respectively). These primary cancers were… More >
Open Access
ARTICLE
Haiying You1, Jing Li2, Xiaojie Wang3, Guodong Zhang4, Juan Yang5,*
Oncologie, Vol.22, No.4, pp. 235-244, 2020, DOI:10.32604/oncologie.2020.014123
Abstract Objective. The purpose was to explore the characteristics and nursing
points of surgical and interventional treatment for elderly cerebral aneurysm.
Methods. 100 elderly patients with cerebral aneurysm treated in our hospital from
January 2017 to December 2019 were selected, and divided into craniotomy group
(40 patients with neurosurgical clipping) and interventional surgery group (60
patients with endovascular interventional embolization) according to the treatment
method to compare the operation time, hospitalization time, hospitalization
expenses, degree of brain injury, complications and prognostic scores of the
patients in two groups. Meanwhile, the relationship between the factors (age,
aneurysm size, location) and prognosis of… More >
Open Access
ARTICLE
Nan Geng1, Wenxia Hu1, Zhikun Liu2, Jingwei Su2, Wenyu Sun3, Shaonan Xie4, Cuimin Ding1,*
Oncologie, Vol.22, No.4, pp. 245-254, 2020, DOI:10.32604/oncologie.2020.014125
Abstract Objective: This study was set out to inquire into the expression and
clinical significance of lncRNA activated by transforming growth factor β
(LncRNA-ATB) and in cancer tissues of patients with non-small cell lung cancer
(NSCLC). Methods: LncRNA-ATB in cancer tissues and adjacent tissues of 89
NSCLC patients was detected by quantitative real-time polymerase chain reaction
(qRT-PCR), and its clinical diagnostic value in NSCLC was determined by receiver
operating characteristic (ROC) curves. Based on the median expression of LncRNAATB in NSCLC tissues, 89 patients were allocated into high- and low-expression
groups. The 3-year survival rate was calculated using Kaplan-Meier method and… More >
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