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ARTICLE
Prognostic and Predictive Significance of Eukaryotic Elongation Factor 1D (eEF1D) in Breast Cancer: A Potential Marker of Response to Endocrine Therapy
Burcu BİTERGE SÜT1,*, Ayşe İKİNCİ KELEŞ2
1 Niğde Ömer Halisdemir University, Faculty of Medicine, Department of Medical Biology, Niğde, Turkey
2 Niğde Ömer Halisdemir University, Faculty of Medicine, Department of Histology and Embryology, Niğde, Turkey
* Corresponding Author: Burcu BİTERGE SÜT. Email:
Oncologie 2020, 22(3), 147-154. https://doi.org/10.32604/oncologie.2020.014449
Abstract
Components of the protein synthesis machinery are subjected to
alterations in cancer cells. eEF1D gene, which lies within the frequently amplified
8q24 locus, is one of the subunits of the human eukaryotic elongation factor
complex. This study aimed to evaluate the prognostic and predictive significance
of eEF1D in breast cancer using in silico analysis tools. For this purpose, we
analyzed genomic alterations of the eEF1D gene using TCGA datasets via
cBioPortal. Histopathological analysis was performed on patient tissue images
obtained from cBioPortal and the Human Protein Atlas. Survival analysis was
carried out using the KM Plotter and the prediction of response to therapy was
assessed via the ROC Plotter. We found that eEF1D was highly amplified and
overexpressed in breast invasive carcinoma. Increased expression of eEF1D was
correlated with increased structural disorganization and morphological alterations
at the cellular level, as well as a shorter period of overall survival. Furthermore,
prediction of response to therapy showed that patients with eEF1D overexpression
responded significantly better to endocrine therapy. In conclusion, our results
suggest a cancer-promoting role for eEF1D, associated with poor prognosis and
points towards its predictive value in providing better tailored treatment options
for a patient.
Keywords
Cite This Article
SÜT, B. B., KELEŞ, A. İ. (2020). Prognostic and Predictive Significance of Eukaryotic Elongation Factor 1D (eEF1D) in Breast Cancer: A Potential Marker of Response to Endocrine Therapy. Oncologie, 22(3), 147–154.
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