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Fadhila Mansour^1,2,*, Abdelhak Lakehal^2,3, Lahcène Nezzal^2,3
Oncologie, Vol.22, No.3, pp. 117-128, 2020, DOI:10.32604/oncologie.2020.014979
Abstract L’objectif de cette étude était de quantifier les délais de prise en charge des femmes atteintes de cancer du sein prises en charge au niveau du centre anticancer de Batna, Algérie. Il s’agissait d’une étude rétrospective à visée descriptive effectuée durant la période Août 2015 à Février 2016. Afin de retracer l’historique du parcours depuis les premiers signes d’apparition du cancer jusqu’aux premiers traitements, un questionnaire a été renseigné à partir des dossiers médicaux et complété par une interview auprès des patientes. 267 patientes ont été incluses dans l’étude. Le délai médian de prise en More >

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ARTICLE

Pallabi Sharma^1,*, Kangkana Bora², Kunio Kasugai³, Bunil Kumar Balabantaray¹
Oncologie, Vol.22, No.3, pp. 129-145, 2020, DOI:10.32604/oncologie.2020.013870
Abstract In this paper, we address a current problem in medical image processing, the detection of colorectal cancer from colonoscopy videos. According to worldwide cancer statistics, colorectal cancer is one of the most common cancers. The process of screening and the removal of pre-cancerous cells from the large intestine is a crucial task to date. The traditional manual process is dependent on the expertise of the medical practitioner. In this paper, a two-stage classification is proposed to detect colorectal cancer. In the first stage, frames of colonoscopy video are extracted and are rated as significant if More >

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Burcu BİTERGE SÜT^1,*, Ayşe İKİNCİ KELE޲
Oncologie, Vol.22, No.3, pp. 147-154, 2020, DOI:10.32604/oncologie.2020.014449
Abstract Components of the protein synthesis machinery are subjected to alterations in cancer cells. eEF1D gene, which lies within the frequently amplified 8q24 locus, is one of the subunits of the human eukaryotic elongation factor complex. This study aimed to evaluate the prognostic and predictive significance of eEF1D in breast cancer using in silico analysis tools. For this purpose, we analyzed genomic alterations of the eEF1D gene using TCGA datasets via cBioPortal. Histopathological analysis was performed on patient tissue images obtained from cBioPortal and the Human Protein Atlas. Survival analysis was carried out using the KM… More >

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CASE REPORT

Ozlem OZ^*
Oncologie, Vol.22, No.3, pp. 155-160, 2020, DOI:10.32604/oncologie.2020.014087
Abstract Neurofibromatosis type 1 is an autosomal dominant disorder which is characterized by multiple café-au-lait spots in the body, intertriginous freckles, Lisch nodules, neurofibroma, optic glioma and bone dysplasia. One of the clinical characteristics of Neurofibromatosis type 1 is the risk of benign and malignant tumor development. Optic gliomas, a type of astrocytoma, are the most common central nervous system complication in children with Neurofibromatosis type 1 and are seen in 10–15% of cases. In this case report, a patient with an optic glioma and a mutation that was not previously identified in the NF1 gene More >

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CASE REPORT

Neslihan Duzkale^1,*, Nilnur Eyerci²
Oncologie, Vol.22, No.3, pp. 161-166, 2020, DOI:10.32604/oncologie.2020.014116
Abstract BRCA1 and BRCA2 tumor suppressor genes are responsible for a quarter of hereditary breast cancers. Double heterozygous (DH) pathogenic variant carrier status in these genes is an extremely rare condition, especially in non-Askenazi individuals. We report a woman patient with bilateral breast cancer that carries DH disease-causing variants in BRCA1/2 genes. The 45-year-old patient who was followed up with the diagnosis of metachronous bilateral breast cancer was diagnosed with cancer at the age of 39 and 43, respectively. BRCA1/2 genes of the patient were evaluated using Next-Generation Sequencing. In the patient, the c.2800C>T (p.Gln934Ter) pathogenic variant in BRCA1… More >

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ARTICLE

Li Bao¹, Xiaowei Tian², Jing Zhang³, Li Chen⁴, Kui Gao^5,*
Oncologie, Vol.22, No.3, pp. 167-178, 2020, DOI:10.32604/oncologie.2020.012495
Abstract Ulinastatin combined with dexmedetomidine can improve postoperative cognitive function and central nerve specific protein (S-100β) level in elderly colorectal cancer (CC) patients after laparoscopic. Altogether 178 elderly patients who underwent laparoscopic colorectal cancer surgery in our hospital from February 2018 to August 2019 were selected and divided into two groups according to the treatment methods. Those anesthetized by dexmedetomidine were regarded as the routine group (RG, 83 cases), and those anesthetized by ulinastatin and dexmedetomidine were considered as the combined group (CG, 95 cases). The operation conditions of the two groups, the pain scores (VAS)… More >

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Yuqin Xie¹, Shuang Deng¹, Qian Deng², Jiudong Xu^*
Oncologie, Vol.22, No.3, pp. 179-188, 2020, DOI:10.32604/Oncologie.2020.012544
Abstract This study aimed to explore LncRNA TUG1 targeted miR-222-3p in the proliferation and invasion of breast cancer (BC) cells. Seventy-six BC patients admitted to our hospital and 62 health check-ups at the same time were selected as the research objects. Among them, the former was seen as the observation group (OG), and the latter was considered as the control group (CG). The clinical significance of LncRNA TUG1 and miR-222-3p in BC was detected. Human BC cell MCF7 and normal human breast epithelial cell MCF-10A were purchased. After cells were transfected with LncRNA TUG1 and miR-222-3p,… More >

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