Open Access
ARTICLE
Fadhila Mansour1,2,*, Abdelhak Lakehal2,3, Lahcène Nezzal2,3
Oncologie, Vol.22, No.3, pp. 117-128, 2020, DOI:10.32604/oncologie.2020.014979
Abstract The objective of this study was to quantify the delays in access to
diagnosis and treatment of women with breast cancer who are managed at the
anticancer center of Batna, Algeria. This was a descriptive retrospective study
conducted during the period August 2015 to February 2016. In order to trace the
history of the journey from the first signs of cancer to the first treatments, a
questionnaire was filled in from the medical files and completed by an interview
with the patients. A total of 267 patients were included in the study. The median
time to management was 4.5 months.… More >
Open Access
ARTICLE
Pallabi Sharma1,*, Kangkana Bora2, Kunio Kasugai3, Bunil Kumar Balabantaray1
Oncologie, Vol.22, No.3, pp. 129-145, 2020, DOI:10.32604/oncologie.2020.013870
Abstract In this paper, we address a current problem in medical image processing,
the detection of colorectal cancer from colonoscopy videos. According to
worldwide cancer statistics, colorectal cancer is one of the most common cancers.
The process of screening and the removal of pre-cancerous cells from the large
intestine is a crucial task to date. The traditional manual process is dependent on
the expertise of the medical practitioner. In this paper, a two-stage classification is
proposed to detect colorectal cancer. In the first stage, frames of colonoscopy video
are extracted and are rated as significant if it contains a polyp, and… More >
Open Access
ARTICLE
Burcu BİTERGE SÜT1,*, Ayşe İKİNCİ KELEŞ2
Oncologie, Vol.22, No.3, pp. 147-154, 2020, DOI:10.32604/oncologie.2020.014449
Abstract Components of the protein synthesis machinery are subjected to
alterations in cancer cells. eEF1D gene, which lies within the frequently amplified
8q24 locus, is one of the subunits of the human eukaryotic elongation factor
complex. This study aimed to evaluate the prognostic and predictive significance
of eEF1D in breast cancer using in silico analysis tools. For this purpose, we
analyzed genomic alterations of the eEF1D gene using TCGA datasets via
cBioPortal. Histopathological analysis was performed on patient tissue images
obtained from cBioPortal and the Human Protein Atlas. Survival analysis was
carried out using the KM Plotter and the prediction of… More >
Open Access
CASE REPORT
Ozlem OZ*
Oncologie, Vol.22, No.3, pp. 155-160, 2020, DOI:10.32604/oncologie.2020.014087
Abstract Neurofibromatosis type 1 is an autosomal dominant disorder which is
characterized by multiple café-au-lait spots in the body, intertriginous freckles,
Lisch nodules, neurofibroma, optic glioma and bone dysplasia. One of the
clinical characteristics of Neurofibromatosis type 1 is the risk of benign and
malignant tumor development. Optic gliomas, a type of astrocytoma, are the
most common central nervous system complication in children with
Neurofibromatosis type 1 and are seen in 10–15% of cases. In this case report, a
patient with an optic glioma and a mutation that was not previously identified in
the NF1 gene is presented in the light… More >
Open Access
CASE REPORT
Neslihan Duzkale1,*, Nilnur Eyerci2
Oncologie, Vol.22, No.3, pp. 161-166, 2020, DOI:10.32604/oncologie.2020.014116
Abstract BRCA1 and BRCA2 tumor suppressor genes are responsible for a quarter
of hereditary breast cancers. Double heterozygous (DH) pathogenic variant carrier
status in these genes is an extremely rare condition, especially in non-Askenazi
individuals. We report a woman patient with bilateral breast cancer that carries DH
disease-causing variants in BRCA1/2 genes. The 45-year-old patient who was
followed up with the diagnosis of metachronous bilateral breast cancer was
diagnosed with cancer at the age of 39 and 43, respectively. BRCA1/2 genes of the
patient were evaluated using Next-Generation Sequencing. In the patient, the
c.2800C>T (p.Gln934Ter) pathogenic variant in BRCA1 and the… More >
Open Access
ARTICLE
Li Bao1, Xiaowei Tian2, Jing Zhang3, Li Chen4, Kui Gao5,*
Oncologie, Vol.22, No.3, pp. 167-178, 2020, DOI:10.32604/oncologie.2020.012495
Abstract Ulinastatin combined with dexmedetomidine can improve
postoperative cognitive function and central nerve specific protein (S-100β) level
in elderly colorectal cancer (CC) patients after laparoscopic. Altogether 178
elderly patients who underwent laparoscopic colorectal cancer surgery in our
hospital from February 2018 to August 2019 were selected and divided into two
groups according to the treatment methods. Those anesthetized by
dexmedetomidine were regarded as the routine group (RG, 83 cases), and those
anesthetized by ulinastatin and dexmedetomidine were considered as the
combined group (CG, 95 cases). The operation conditions of the two groups, the
pain scores (VAS) at 4 h, 24 h… More >
Open Access
ARTICLE
Yuqin Xie1, Shuang Deng1, Qian Deng2, Jiudong Xu*
Oncologie, Vol.22, No.3, pp. 179-188, 2020, DOI:10.32604/Oncologie.2020.012544
Abstract This study aimed to explore LncRNA TUG1 targeted miR-222-3p in
the proliferation and invasion of breast cancer (BC) cells. Seventy-six BC patients
admitted to our hospital and 62 health check-ups at the same time were selected as
the research objects. Among them, the former was seen as the observation group
(OG), and the latter was considered as the control group (CG). The clinical
significance of LncRNA TUG1 and miR-222-3p in BC was detected. Human BC
cell MCF7 and normal human breast epithelial cell MCF-10A were purchased.
After cells were transfected with LncRNA TUG1 and miR-222-3p, their
proliferation, invasion, and apoptosis… More >
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