Open Access
ARTICLE
The Relationship BRCA1/2 Genes and Family History in Ovarian Cancers
Neslihan Duzkale1,*, Hikmet Taner Teker2
1 Department of Medical Genetics, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
2 Department of Molecular Biology, Middle East Technical University, Ankara, Turkey
* Corresponding Author: Neslihan Duzkale. Email:
Oncologie 2020, 22(2), 65-74. https://doi.org/10.32604/oncologie.2020.013707
Abstract
BRCA1/2 genes are responsible for the hereditary breast and ovarian
cancer syndrome. In this study, Turkish women with ovarian cancer were
investigated in terms of demographic, clinicopathologic and family cancer stories
according to their condition of the
BRCA1/2 genes mutation carrier. During 2011
to 2017 in Turkey,
BRCA1 and
BRCA2 genes were analyzed in 38 women, who
were diagnosed with cancer using Next Generation Sequencing technique.
Pathogenic mutations were detected in 9 (23.7%) of patients. The diagnosis age
for Ovarian cancer patients for
BRCA1/2 mutation carriers was found higher. It
was seen that mutations mostly occurred in the
BRCA2 gene and frameshift
mechanism and they were located in exon10 in the
BRCA1 gene and especially
in exon11 in the
BRCA2 gene. According to the applied logistic regression model,
it was found that patients with more than two relatives having cancer would have
a 12.844 fold and high risk of being a
BRCA1/2 mutation carrier. In women with
ovarian cancer,
BRCA1/2 gene mutations are observed more frequently in certain
exons of these genes.
BRCA1 mutation carriers are diagnosed with ovarian
cancer earlier than
BRCA2 mutation carriers. In hereditary ovarian cancers,
besides
BRCA1/2, many identified genes and many modifier candidate genes that
are waiting to be discovered can cause this condition. In the family history, the
numerical increase of cancerous relatives significantly increases the risk of
BRCA1/2 carrying mutation.
Keywords
Cite This Article
APA Style
Duzkale, N., Teker, H.T. (2020). The relationship brca1/2 genes and family history in ovarian cancers. Oncologie, 22(2), 65-74. https://doi.org/10.32604/oncologie.2020.013707
Vancouver Style
Duzkale N, Teker HT. The relationship brca1/2 genes and family history in ovarian cancers. Oncologie . 2020;22(2):65-74 https://doi.org/10.32604/oncologie.2020.013707
IEEE Style
N. Duzkale and H.T. Teker, "The Relationship BRCA1/2 Genes and Family History in Ovarian Cancers," Oncologie , vol. 22, no. 2, pp. 65-74. 2020. https://doi.org/10.32604/oncologie.2020.013707