Open Access

ARTICLE

Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors

Chuanwei Xu¹, Renju Ding², Chuanping Xu^3,*

1 Department of Breast and Thyroid Surgery, Linyi Hospital of Traditional Chinese Medicine, Linyi, China
2 The First Department of Lung Disease, Linyi Hospital of Traditional Chinese Medicine, Linyi, China
3 Linyi Tumor Hospital, Linyi, China

* Corresponding Author: Chuanping Xu. Email:

Oncologie 2020, 22(1), 43-51. https://doi.org/10.32604/oncologie.2020.012445

Abstract

To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than in the CG on the third, fifth, and seventh days after the operation, but the IL-35 levels were higher than those in the CG (p < 0.05). There were no cases of relapse in the OG, and the DTC relapse rate was lower than that of the CG (15.38%) (p < 0.05). The differences in age; lesion diameter; serum IL-17, IL-35, and SIL-2R expression levels; AJCC thyroid cancer stage; and disease type between DTC relapse and relapse-free patients were statistically significant (p < 0.05). Older age; higher IL-17, lower IL- 35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and disease type were positively correlated with DTC relapse (p < 0.05). Compared with subtotal thyroidectomy, total thyroidectomy for the treatment of thyroid cancer has greater advantages in improving immune inflammation and reducing the relapse rate. Older age; higher IL-17, lower IL-35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and disease type are independent risk factors affecting thyroid cancer relapse after surgery. These findings can reference the selection of clinical surgery procedures in the treatment of thyroid cancer.

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