Open Access

ARTICLE

Sinomenium Inhibits the Viability of Hepatoma Carcinoma Cells through Activating IFNA2

Jingjing He^1,2, Lingyi Zhang², Dan Guo³, Xingwen Han⁴, Hui Zhang⁵, Liang Wang², Youcheng Zhang^1,*

1 The Second Clinical Medical College of Lanzhou University, Lanzhou, 730000, China
2 The Department of Liver Disease of the Second Hospital of Lanzhou University, Lanzhou, 730000, China
3 Pneumology Department of Gansu Gem Flower Hospital (Lanzhou Petrochemical General Hospital), Lanzhou, 730000, China
4 Orthopedics Department of the First Hospital of Lanzhou University, Lanzhou, 730000, China
5 Peking University People’s Hospital, Beijing, 100000, China

* Corresponding Author: Youcheng Zhang. Email:

Oncologie 2020, 22(1), 1-12. https://doi.org/10.32604/oncologie.2020.012436

Abstract

Hepatocellular carcinoma (HCC) ranks the sixth place of most common cancers. Meanwhile, it is the tertiary mortality cause of cancer. There is no effective therapeutic method to prevent and treat the liver cancer. Sinomenine is a kind of Chinese traditional medicine herbal, it is reported that it can inhibit the viability of several cancer cells. The study is to explore whether sinomenine is also able to inhibit the cell viability of HCC and its potential mechanism. The IC50 of sinomenine in BEL-7402 cells was 5.351 mmol/L, and the IC50 of sinomenine in SMMC-7721 cells was 6.204 mmol/L. The gene expression results showed the relative expression of FGF2, CCND2, DCN, F3, MMP7, NRG1, HMGB1, TRIM29, HAS2, EHF, CTGF, PLK2 were down-regulated, and the relative expression of VEGF A, CITED2, NUPR1, DDX58, IRF9, NAMPT, MMP1, NDRG1, HMGA2, PPARGC1A, IFIT2, PARP9, HEY1, LOX, ETV1, ISG15, BACH, CYLD were up-regulated. Moreover, the IPA analysis results suggested that IFIT3, IFIT1, OAS1, MX1, IRF9, IFI6, IFITM1, ISG15 were up-regulated in BEL-7402 cells treated with sinomenine by activating IFNA2. The findings presented in this study may provide a promising method for the prevention and treatment of liver cancer.

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