Ferroptosis in the Occurrence and Treatment of Cancer

Submission Deadline: 31 January 2023 (closed)

Guest Editors

Prof. Xiao-Bin Lv, The third Affiliated Hospital of Nanchang University, the First Hospital of Nanchang, Nanchang, China.
Email: nclvxiaobin@sina.cn

Prof. Guoliang Huang, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Guangzhou, China.
Email: huangguoliang@gdmu.edu.cn

Summary

Ferroptosis is a newly identified mode of programmed cell death characterized by an excess iron accumulation and subsequent unbalanced redox states. The molecular mechanism of ferroptosis is mainly dependent on the production and elimination of lipid peroxidation. When the peroxidation excess the capability which the cells could remove effectively through an antioxidative mechanism, the accumulation of peroxidative lipids induces ferroptosis. Many physiological processes including iron metabolism, amino acid metabolism, and lipid metabolism and a variety of gene-coding products including proteins, lncRNA, and miRNA, are implicated in ferroptosis.

Recently, growing studies have reported that chemotherapy, radiotherapy, and checkpoint therapy induce ferroptosis of cancer cell and the dysregulated ferroptosis could lead to the resistance of cancer to these therapies. Targeting ferroptosis-related signaling pathway could be new strategy for cancer therapy.

The objective of this Research Topic is to give a comprehensive overview of the regulatory mechanisms of ferroptosis and its potential applications in cancer treatment. We welcome Original Research, Reviews, Viewpoints etc., focusing on but not limited to the following topics:

 

1) Signaling pathways that regulate the cancer progression related to ferroptosis.

2) LncRNAs and miRNAs as the regulators of ferroptosis related to cancer.

3) Ferroptosis-related resistance or sensitivity to all kinds of cancer treatments.


Keywords

ferroptosis, cancer, peroxidative, iron

Published Papers


  • Open Access

    REVIEW

    Ferroptosis’s Role in Genitourinary System Cancer

    Chaoying Liu, Xinfeng Yang, Ye Wang, Keyu Wu, Siqiang Li, Gailing Wang, Yun Li, Chuanfeng Li, Mingcheng Wang, Enzhong Li
    Oncologie, Vol.24, No.4, pp. 679-691, 2022, DOI:10.32604/oncologie.2022.025705
    (This article belongs to this Special Issue: Ferroptosis in the Occurrence and Treatment of Cancer)
    Abstract A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new… More >

  • Open Access

    ARTICLE

    Comprehensive Analysis of the Expression and Clinical Significance of a Ferroptosis-Related Genome in Ovarian Serous Cystadenocarcinoma: A Study Based on TCGA Data

    Hua Yang
    Oncologie, Vol.24, No.4, pp. 835-863, 2022, DOI:10.32604/oncologie.2022.026447
    (This article belongs to this Special Issue: Ferroptosis in the Occurrence and Treatment of Cancer)
    Abstract Background: Epithelial ovarian cancer (EOC) is the deadliest malignancy among the gynecologic tumors, and ovarian serous cystadenocarcinoma (OV) is the dominant histological type. Ferroptosis is a novel iron-dependent, programmed form of cell death, and agents that trigger ferroptosis may constitute potential anti-cancer therapies. Materials and Methods: We herein extracted the genes that participate in the process of ferroptosis from the online FerrDb database to create a ferroptosis-related genome (FRG), and then comprehensively analyzed the relationship between the mRNA expression of each gene and the clinicopathologic features of The Cancer Genome Atlas (TCGA)-OV cohort. Results: We found that most of the… More >

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