Guest Editors
Wenwen Zhang
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
wwzhang1022@hotmail.com
Xiaoxiang Guan
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
xguan@njmu.edu.cn
Summary
Breast cancer is one of the most common malignancies, and its incidence is the highest among female cancers. Recent studies have shown that breast cancer cases has surpassed lung cancer as the most prevalent malignancy worldwide in 2020. In the early stages of breast cancer, surgery can achieve a good therapeutic outcome or even complete cure. However, due to the insidious onset and rapid progression of breast cancer, some patients are diagnosed even when the tumor has progressed to the middle and late stages, missing the best time for surgical treatment. Therefore, effective biomarkers for breast cancer diagnosis are urgently needed.
In recent years, with the tremendous progress in molecular biology technology, the molecular mechanisms involved in the development of breast cancer have received sufficient attention and focused research. Researchers are screening new therapeutic biomarkers for breast cancer and exploring the molecular mechanisms underlying their effects on the biological properties of breast cancer. Currently, multiple molecules or signaling pathways that play key roles in breast cancer progression have been elucidated. Designing biologically precise therapies against these relevant targets or receptors can improve the killing power of drugs on breast cancer cells while reducing the damage to normal cells. These findings provide new perspectives and strategies for clinical individualized treatment of breast cancer.
In this topic, we aim to collect original research articles, reviews, mini-reviews, commentaries and opinions focused on the recent advances of predictive and prognostic biomarkers for breast cancer. Topics of interest include, but are not limited to:
1) Identification of novel biomarkers for breast cancer phenotyping and treatment option selection.
2) The molecular mechanism of biomarkers regulating the development of breast cancer.
3) Developing biomarkers-based diagnostics and therapeutics in breast cancer.
Keywords
Breast cancer, Biomarkers, Prognosis, Diagnosis, Targeted therapy
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