Open Access

ARTICLE

IVUS-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment

Haofei Liu^*, Mingchao Cai^*, Chun Yang^∗,†, Jie Zheng^‡, Richard Bach^§, Mehmet H. Kural^¶, Kristen L. Billiar^¶, David Muccigrosso^‡, Dongsi Lu^||, Dalin Tang^∗,∗∗

* Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609
† School of Mathematical Sciences, Beijing Normal University, Key Laboratory of Mathematics and Complex Systems, Ministry of Education, Beijing, 100875, China
‡ Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110 USA
§ Cardiovascular Division, Washington University School of Medicine, Saint Louis, MO 63110, USA
¶ Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609
|| Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
∗∗ Dalin Tang, Corresponding author, 508-845-1575, dtang@wpi.edu

Molecular & Cellular Biomechanics 2012, 9(1), 77-94. https://doi.org/10.3970/mcb.2012.009.077

Abstract

Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated.

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Keywords

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