Open Access

ARTICLE

Simulation and Modeling of Laser-Tissue Interactions Based on a Liposome-Dye System

by F.E. Mensah∗ ,†^†, R. Sridhar†^†, P. Misra†^†

∗ University of the District of Columbia, Washington, DC, USA
† Howard University, Washington, DC, USA

Molecular & Cellular Biomechanics 2010, 7(4), 203-212. https://doi.org/10.3970/mcb.2010.007.203

Abstract

This work presents an overview of the use of liposomes for targeted delivery of photosensitizers to tumors for Photodynamic Therapy (PDT). It assesses the results of a quantitative model to explain the interaction of short-pulsed lasers (in the nanosecond and picosecond domains) with a liposome-dye complex in terms of a localized photo-induced thermal mechanism. Incorporation of an organic dye (sulforhodamine) within lipid vesicles has been investigated in conjunction with the effect of laser irradiation on the integrity of the liposome-dye complex. The variation of the absorption coefficient as a function of wavelength for dye-encapsulated liposomes before and after laser-induced release of dye was studied and modeled. The commercial softwareMathematicawas used to develop a Gaussian model for the energy absorption by the liposome-dye complex. Dye release from 3mm - liposome encapsulating 25 mM aqueous solution of sulforhodamine dye was studied using 8 ns laser pulses at the second harmonic of the Nd:YAG laser (at 532 nm) and compared with dye release employing 25 ps - laser pulses. In addition, the temperature-dependence of the dye release has been included in the photo-thermal model.

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Keywords

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