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Simulation and Modeling of Laser-Tissue Interactions Based on a Liposome-Dye System

F.E. Mensah∗,†, R. Sridhar, P. Misra

University of the District of Columbia, Washington, DC, USA
Howard University, Washington, DC, USA

Molecular & Cellular Biomechanics 2010, 7(4), 203-212.


This work presents an overview of the use of liposomes for targeted delivery of photosensitizers to tumors for Photodynamic Therapy (PDT). It assesses the results of a quantitative model to explain the interaction of short-pulsed lasers (in the nanosecond and picosecond domains) with a liposome-dye complex in terms of a localized photo-induced thermal mechanism. Incorporation of an organic dye (sulforhodamine) within lipid vesicles has been investigated in conjunction with the effect of laser irradiation on the integrity of the liposome-dye complex. The variation of the absorption coefficient as a function of wavelength for dye-encapsulated liposomes before and after laser-induced release of dye was studied and modeled. The commercial softwareMathematicawas used to develop a Gaussian model for the energy absorption by the liposome-dye complex. Dye release from 3mm - liposome encapsulating 25 mM aqueous solution of sulforhodamine dye was studied using 8 ns laser pulses at the second harmonic of the Nd:YAG laser (at 532 nm) and compared with dye release employing 25 ps - laser pulses. In addition, the temperature-dependence of the dye release has been included in the photo-thermal model.


Cite This Article

Mensah, F., Sridhar, R., Misra, P. (2010). Simulation and Modeling of Laser-Tissue Interactions Based on a Liposome-Dye System. Molecular & Cellular Biomechanics, 7(4), 203–212.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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