Open Access

ARTICLE

Cyclic Bending Contributes to High Stress in a Human Coronary Atherosclerotic Plaque and Rupture Risk: In Vitro Experimental Modeling and Ex Vivo MRI-Based Computational Modeling Approach

Chun Yang^∗,†, Dalin Tang^∗,‡, Shunichi Kobayashi^§, Jie Zheng^¶, Pamela K. Woodard^§, Zhongzhao Teng^*, Richard Bach^||, David N. Ku^∗∗

∗ Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609
† Schoolof MathematicalSciences,Beijing NormalUniversity, Beijing, China
‡ Corresponding author. Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, Phone: 508-831-5332, Fax: 508-831-5824, E-mail: dtang@wpi.edu
§ Division of Creative Engineering, Shinshu University, Ueda, Nagano, Japan
¶ Mallinkcrodt Inst. of Radiology, Washington University, St. Louis, MO 63110, USA
|| Division of Cardiovascular Diseases, Washington University, St. Louis, MO 63110, USA
∗∗ School of Mechanical Engineering, Georgia Institute of Technology,Atlanta, GA, 30332-0405USA